KIF7 Antibody (3F8): sc-517550
- KIF7 Antibody (3F8) is a mouse monoclonal IgG KIF7 antibody provided at 100 µg/ml
- raised against Kif 7 proteins of human origin
- recommended for detection of Kif 7 of mouse, rat and human origin by IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KIF7 Antibody (3F8). This work is in progress.
KIF7 Antibody (3F8) is a mouse monoclonal IgG antibody that detects KIF7 protein of mouse, rat, and human origin by immunofluorescence (IF) and immunohistochemistry. Anti-KIF7 antibody (3F8) is available as a non-conjugated format. KIF7, or kinesin family member 7, is a vital protein composed of 1,343 amino acids, predominantly expressed in embryonic stem cells, melanotic melanoma, and Jurkat T-cells. KIF7 is a member of the KIF27 subfamily within the kinesin-like protein family and features a single kinesin-motor domain, which is essential for its function as a microtubule-dependent motor protein. KIF7 plays a significant role in the Hedgehog (Hh) signaling pathway, which is crucial for embryonic development, by regulating the proteolysis and stability of GLI transcription factors. Proper functioning of KIF7 is important because dysregulation of the Hedgehog signaling pathway can lead to developmental disorders and various cancers. Using KIF7 (3F8) antibody in research can provide insights into the mechanisms of intracellular transport and the implications of KIF7 in developmental biology and disease.
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KIF7 Antibody (3F8) References:
- Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. | Chen, MH., et al. 2005. Mol Cell Biol. 25: 7042-53. PMID: 16055716
- Hedgehog signaling pathway and gastric cancer. | Katoh, Y. and Katoh, M. 2005. Cancer Biol Ther. 4: 1050-4. PMID: 16258256
- WNT antagonist, SFRP1, is Hedgehog signaling target. | Katoh, Y. and Katoh, M. 2006. Int J Mol Med. 17: 171-5. PMID: 16328026
- Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). | Katoh, Y. and Katoh, M. 2006. Int J Mol Med. 18: 1019-23. PMID: 17089004
- Cloning and developmental expression of kinesin superfamily7 (kif7) in the brackish medaka (Oryzias melastigma), a close relative of the Japanese medaka (Oryzias latipes). | Ho, NY., et al. 2008. Mar Pollut Bull. 57: 425-32. PMID: 18423496
- The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. | Cheung, HO., et al. 2009. Sci Signal. 2: ra29. PMID: 19549984
- The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. | Endoh-Yamagami, S., et al. 2009. Curr Biol. 19: 1320-6. PMID: 19592253
- Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. | Liem, KF., et al. 2009. Proc Natl Acad Sci U S A. 106: 13377-82. PMID: 19666503
- Hedgehog signalling: Kif7 is not that fishy after all. | Ingham, PW. and McMahon, AP. 2009. Curr Biol. 19: R729-31. PMID: 19906571
- KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. | Putoux, A., et al. 2011. Nat Genet. 43: 601-6. PMID: 21552264
- Sufu and Kif7 in limb patterning and development. | Zhulyn, O. and Hui, CC. 2015. Dev Dyn. 244: 468-78. PMID: 25581370
- KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition. | Wong, KY., et al. 2017. Oncotarget. 8: 54558-54571. PMID: 28903364
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIF7 Antibody (3F8) | sc-517550 | 100 µg/ml | $322.00 |