Katanin p80 B1 Antibody (C-4): sc-377226
- Katanin p80 B1 Antibody (C-4) is a mouse monoclonal IgG1 κ Katanin p80 B1 antibody provided at 200 µg/ml
- raised against amino acids 356-655 mapping at the C-terminus of Katanin p80 B1 of human origin
- Katanin p80 B1 Antibody (C-4) is recommended for detection of Katanin p80 B1 of human origin by WB, IP, IF and ELISA
- Anti-Katanin p80 B1 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Katanin p80 B1 Antibody (C-4) for WB applications. This reagent is now offered in a bundle with Katanin p80 B1 Antibody (C-4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
Katanin p80 B1 Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Katanin p80 B1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Katanin p80 B1 antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Katanin p80 B1 plays a crucial role in microtubule dynamics, which are essential for various cellular processes, including cell division and intracellular transport. Specifically, Katanin p80 B1 is part of a heterodimeric complex that severs microtubules in an ATP-dependent manner, facilitating reorganization of microtubule arrays and release of microtubules from the centrosome after nucleation. This function is vital for maintaining proper cellular architecture and ensuring accurate chromosome segregation during mitosis. The Katanin complex consists of a 60 kDa subunit (Katanin p60 A1), which is responsible for the severing action, and an 80 kDa accessory protein (Katanin p80 B1), which targets the complex to the centrosome, highlighting the importance of both subunits in microtubule regulation and cellular function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Katanin p80 B1 Antibody (C-4) References:
- An essential role for katanin in severing microtubules in the neuron. | Ahmad, FJ., et al. 1999. J Cell Biol. 145: 305-15. PMID: 10209026
- Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. | McNally, KP., et al. 2000. J Cell Sci. 113 (Pt 9): 1623-33. PMID: 10751153
- Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. | Karabay, A., et al. 2004. J Neurosci. 24: 5778-88. PMID: 15215300
- Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. | Toyo-Oka, K., et al. 2005. Hum Mol Genet. 14: 3113-28. PMID: 16203747
- LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. | Sudo, H. and Maru, Y. 2008. Hum Mol Genet. 17: 2524-40. PMID: 18490357
- Identification of katanin, an ATPase that severs and disassembles stable microtubules. | McNally, FJ. and Vale, RD. 1993. Cell. 75: 419-29. PMID: 8221885
- Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. | McNally, FJ., et al. 1996. J Cell Sci. 109 (Pt 3): 561-7. PMID: 8907702
- Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. | Hartman, JJ., et al. 1998. Cell. 93: 277-87. PMID: 9568719
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Katanin p80 B1 Antibody (C-4) | sc-377226 | 200 µg/ml | $322.00 | |||
Katanin p80 B1 Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-523240 | 200 µg Ab, 40 µg BP | $361.00 | |||
Katanin p80 B1 Antibody (C-4) AC | sc-377226 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Katanin p80 B1 Antibody (C-4) HRP | sc-377226 HRP | 200 µg/ml | $322.00 | |||
Katanin p80 B1 Antibody (C-4) FITC | sc-377226 FITC | 200 µg/ml | $336.00 | |||
Katanin p80 B1 Antibody (C-4) PE | sc-377226 PE | 200 µg/ml | $349.00 | |||
Katanin p80 B1 Antibody (C-4) Alexa Fluor® 488 | sc-377226 AF488 | 200 µg/ml | $364.00 | |||
Katanin p80 B1 Antibody (C-4) Alexa Fluor® 546 | sc-377226 AF546 | 200 µg/ml | $364.00 | |||
Katanin p80 B1 Antibody (C-4) Alexa Fluor® 594 | sc-377226 AF594 | 200 µg/ml | $364.00 | |||
Katanin p80 B1 Antibody (C-4) Alexa Fluor® 647 | sc-377226 AF647 | 200 µg/ml | $364.00 | |||
Katanin p80 B1 Antibody (C-4) Alexa Fluor® 680 | sc-377226 AF680 | 200 µg/ml | $364.00 | |||
Katanin p80 B1 Antibody (C-4) Alexa Fluor® 790 | sc-377226 AF790 | 200 µg/ml | $364.00 |