Integrin β3/ITGB3/CD61 Antibody (5K291): sc-71407

Integrin β3 Antibody (5K291) is a mouse monoclonal IgG1 antibody that detects Integrin β3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin β3 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Specifically, Integrin β3 pairs with various α subunits to form receptors that mediate cell adhesion to the extracellular matrix, playing a vital role in processes such as wound healing, immune response, and tissue repair. Integrin β3 is predominantly located on the cell surface, where anti-Integrin β3 antibody (5K291) detects interactions with ligands like fibronectin and vitronectin, facilitating cell signaling and communication. These interactions are essential for the activation of integrin-mediated responses, which include cell migration and proliferation. Furthermore, Integrin β3 undergoes post-translational modifications, such as glycosylation, which can influence function and stability, thereby impacting cellular behavior and responses to external stimuli. The ability of Integrin β3 to form complexes with other proteins, including integrin αv, enhances functional diversity and underscores importance in various physiological and pathological processes. Integrin β3 (5K291) monoclonal antibody serves as an invaluable tool for researchers studying cell adhesion mechanisms and integrin signaling pathways in human tissues.

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.