Indatraline hydrochloride CAS: 96850-13-4
MF: C16H15Cl2N.HCl
MW: 328.67
An inhibitor of ST, DAT, and SLC6A2.

Indatraline hydrochloride (CAS 96850-13-4)

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Alternate Names: (±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride; Lu 19-005
Application Indatraline hydrochloride is an inhibitor of ST, DAT, and SLC6A2
CAS 등록번호: 96850-13-4
분자량: 328.67
분자식: C16H15Cl2N.HCl
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Indatraline hydrochloride is a strong monoamine uptake inhibitor which inhibits the transporters ST (serotonin/SERT) (Ki = 0.42 nM), DAT (dopamine) (Ki = 1.7 nM), and SLC6A2 (noradrenalin/NET) (Ki = 5.8 nM).


References

1. Hyttel, J. and Larsen, J.J. 1985. J. Neurochem. 44: 1615-1622.
2. Negus, S.S., et al. 1999. J. Pharmacol. Exp. Ther. 291: 60-69.
3. Gu, X.H., et al. 2000. J. Med. Chem. 43: 4868-4876.

Physical State :
Solid
용해도 :
Soluble in water (25 mM), ethanol (50 mM), and DMSO (100 mM).
저장 :
Desiccate at 4° C
IC50 :
Plasmodium falciparum: IC50 = 3.98 µM
Ki 데이타 :
ST: Ki= 0.42 nM; DAT: Ki= 1.7 nM; SLC6A2: Ki= 5.8 nM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00083178
SMILES :
CN[[email protected]@H]1C[[email protected]](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

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