IFN-γRβ Antibody (A-11): sc-377291
- IFN-γRβ Antibody (A-11) is a mouse monoclonal IgG1 κ IFN-γRβ antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 28-337 of IFN-γRβ of human origin
- IFN- gamma R beta Antibody (A-11) is recommended for detection of IFN-γRβ of human origin by WB, IP, IF and ELISA
- Anti-IFN- gamma R beta Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for IFN-γRβ Antibody (A-11) for WB applications. This reagent is now offered in a bundle with IFN-γRβ Antibody (A-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
SEE ALSO...
IFN-γRβ Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects human IFN-γRβ by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-γRβ Antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IFN-γRβ plays a crucial role in immune response as an essential component of the signaling pathway activated by interferon-gamma (IFN-γ), a key cytokine involved in antiviral and immunomodulatory activities. The receptor complex, including both IFN-γRα and IFN-γRβ, enables transcriptional activation of IFN-γ-responsive genes, influencing cell proliferation and differentiation. IFN-γRβ, also known as AF-1, comprises 332 amino acids in mice and 337 amino acids in humans, functioning as the signal transducing component of the receptor. Proper functioning of IFN-γRβ is critical for effective immune responses to pathogens, making research on this protein essential for understanding immune responses and developing therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-γRβ Antibody (A-11) References:
- IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk. | Jemli, A., et al. 2017. Nord J Psychiatry. 71: 42-47. PMID: 27563937
- The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies. | Novick, D., et al. 1987. J Biol Chem. 262: 8483-7. PMID: 2954953
- Molecular cloning and expression of the human interferon-gamma receptor. | Aguet, M., et al. 1988. Cell. 55: 273-80. PMID: 2971451
- Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis. | Bogers, L., et al. 2024. J Autoimmun. 148: 103279. PMID: 38972102
- Type I and Type II interferon receptors. | Orchansky, P., et al. 1984. J Interferon Res. 4: 275-82. PMID: 6086780
- Interferon-induced nuclear signalling by Jak protein tyrosine kinases. | Silvennoinen, O., et al. 1993. Nature. 366: 583-5. PMID: 7504785
- Recent progress in the elucidation of interferon-gamma actions: molecular biology and biological functions. | Vilcek, J. and Oliveira, IC. 1994. Int Arch Allergy Immunol. 104: 311-6. PMID: 8038608
- Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. | Soh, J., et al. 1994. Cell. 76: 793-802. PMID: 8124716
- A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. | Hemmi, S., et al. 1994. Cell. 76: 803-10. PMID: 8124717
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
- The molecular cell biology of interferon-gamma and its receptor. | Farrar, MA. and Schreiber, RD. 1993. Annu Rev Immunol. 11: 571-611. PMID: 8476573
- Sézary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain). | Dummer, R., et al. 1996. Blood. 88: 1383-9. PMID: 8695857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γRβ Antibody (A-11) | sc-377291 | 200 µg/ml | $322.00 | |||
IFN-γRβ Antibody (A-11): m-IgGκ BP-HRP Bundle | sc-523269 | 200 µg Ab, 40 µg BP | $361.00 | |||
IFN-γRβ Antibody (A-11) AC | sc-377291 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IFN-γRβ Antibody (A-11) HRP | sc-377291 HRP | 200 µg/ml | $322.00 | |||
IFN-γRβ Antibody (A-11) FITC | sc-377291 FITC | 200 µg/ml | $336.00 | |||
IFN-γRβ Antibody (A-11) PE | sc-377291 PE | 200 µg/ml | $349.00 | |||
IFN-γRβ Antibody (A-11) Alexa Fluor® 488 | sc-377291 AF488 | 200 µg/ml | $364.00 | |||
IFN-γRβ Antibody (A-11) Alexa Fluor® 546 | sc-377291 AF546 | 200 µg/ml | $364.00 | |||
IFN-γRβ Antibody (A-11) Alexa Fluor® 594 | sc-377291 AF594 | 200 µg/ml | $364.00 | |||
IFN-γRβ Antibody (A-11) Alexa Fluor® 647 | sc-377291 AF647 | 200 µg/ml | $364.00 | |||
IFN-γRβ Antibody (A-11) Alexa Fluor® 680 | sc-377291 AF680 | 200 µg/ml | $364.00 | |||
IFN-γRβ Antibody (A-11) Alexa Fluor® 790 | sc-377291 AF790 | 200 µg/ml | $364.00 |