IFN-γ/Interferon gamma Antibody (J-7): sc-74106
- IFN-γ/Interferon gamma Antibody (J-7) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against full length recombinant IFN-γ of rat origin
- recommended for detection of IFN-γ of mouse and rat origin by WB and ELISA
- also provided azide-free for neutralizing, sc-74106 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (J-7). This work is in progress.
IFN-γ Antibody (J-7) is a mouse monoclonal IgG1 antibody that detects interferon gamma (IFN-γ) in mouse and rat samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-IFN-γ antibody (J-7) plays a crucial role in the immune response, as IFN-γ is primarily produced by activated CD4+/CD8+ lymphocytes and natural killer cells, serving as a potent antiviral and antiparasitic agent. IFN-γ (J-7) antibody helps study a protein vital for modulating T cell growth and differentiation while inhibiting B cell proliferation, thereby orchestrating a balanced immune response. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices, which is essential for biological activity. The precursor of IFN-γ consists of 166 amino acids, including a 23 amino acid secretory sequence, and functionality is further influenced by post-translational modifications such as glycosylation, which can lead to the formation of multiple isoforms under non-denaturing conditions, including dimers and tetramers. IFN-γ′s ability to interact with various signaling pathways highlights its importance in immune regulation and potential as a therapeutic target in diseases characterized by immune dysregulation.
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IFN-γ/Interferon gamma Antibody (J-7) References:
- Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. | Ting, LM., et al. 1999. J Immunol. 163: 3898-906. PMID: 10490990
- IFN-gamma alters the pathology of graft rejection: protection from early necrosis. | Halloran, PF., et al. 2001. J Immunol. 166: 7072-81. PMID: 11390451
- IGF-1 down-regulates IFN-gamma R2 chain surface expression and desensitizes IFN-gamma/STAT-1 signaling in human T lymphocytes. | Bernabei, P., et al. 2003. Blood. 102: 2933-9. PMID: 12842994
- Endogenous accumulation of IFN-gamma in IFN-gamma-R(-/-) mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo. | Rodrigues, EG., et al. 2002. Cytokines Cell Mol Ther. 7: 107-16. PMID: 12850810
- IFN-gamma is an absolute requirement for spontaneous acceptance of liver allografts. | Mele, TS., et al. 2003. Am J Transplant. 3: 942-51. PMID: 12859528
- Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. | Lees, JR., et al. 2008. J Exp Med. 205: 2633-42. PMID: 18852291
- IFN-gamma and b7 as costimulators of antitumor immune-responses. | Flores, I., et al. 1995. Int J Oncol. 7: 501-9. PMID: 21552866
- JUNB/AP-1 controls IFN-γ during inflammatory liver disease. | Thomsen, MK., et al. 2013. J Clin Invest. 123: 5258-68. PMID: 24200694
- OTUB1 inhibits CNS autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes. | Wang, X., et al. 2019. EMBO J. 38: PMID: 30944096
- Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis. | Carvalho, EM., et al. 1994. J Immunol. 152: 5949-56. PMID: 8207220
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (J-7) | sc-74106 | 100 µg/ml | $322.00 | |||
IFN-γ/Interferon gamma Antibody (J-7) L | sc-74106 L | 100 µg/0.1 ml | $322.00 |