Idebenone CAS: 58186-27-9
MF: C19H30O5
MW: 338.44
An antioxidant and neuroprotective agent.

Idebenone (CAS 58186-27-9)

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Synonym: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Application An antioxidant and neuroprotective agent
CAS 등록번호: 58186-27-9
순도: ≥98%
분자량: 338.44
분자식: C19H30O5
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Idebenone, a neuroprotective agent, has been shown to act as a free radical scavenger and protect mitochondrial membranes against lipid peroxidation. This compound has also been found to prevent platelet aggregation and recover cholinergic and monoaminergic changes in murine models. Other studies show that Idebenone displays a capacity to increase nerve growth factor production in cultured rat astrocytes. Additionally, this agent has been reported to dose-dependently inhibit enzymatic metabolism of Arachidonic Acid (sc-200770) in astroglial homogenates.


References

1. Zs -Nagy, I. 1990. Arch Gerontol Geriatr. 11: 177-186. PMID: 15374467
2. Civenni, G., et al. 1999. Eur. J. Pharmacol. 370: 161-167. PMID: 10323265
3. Takuma, K., et al. 2000. Eur. J. Pharmacol. 406: 333-339. PMID: 11040339

Physical State :
Solid
용해도 :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), methanol, and chloroform. Insoluble in water.
저장 :
Store at room temperature
녹는점 :
~192.68° C (Predicted)
비등점 :
~497.3° C at 760 mmHg (Predicted)
밀도 :
~1.1 g/cm3 (Predicted)
굴절률 :
n20D 1.50
IC50 :
Rattus norvegicus: IC50 = 1300 nM (Rattus norvegicus); Brain: IC50 = 31500 nM (Rattus norvegicus)
pK Values :
pKa: 15.19
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
GU5290000
PubChem CID :
3686
Merck Index :
14: 4888
MDL Number :
MFCD00274552
Beilstein Registry :
2001459
SMILES :
CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO

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분석증명서

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Idebenone  논문정보

다른 사용자의 Idebenone사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 2 of {3} total

PMID: # 9840428  Hirai, K. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 358: 582-585.

PMID: # 31783691  Cancers (Basel). 11:

Citations 1 to 2 of {3} total
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