아미노 산491-535 mapping at the C-terminus of HPA1 of mouse 의하고 기원한다
안티-HPA1 항체 (E-10)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 HPA1 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-HPA1 항체 (E-10)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for HPA1 Antibody (E-10) for WB applications. This reagent is now offered in a bundle with HPA1 Antibody (E-10) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
HPA1 Antibody (E-10) is a high quality monoclonal HPA1 antibody (also designated HPA1 antibody) suitable for the detection of the HPA1 protein of mouse, rat and human origin. HPA1 Antibody (E-10) is available as both the non-conjugated anti-HPA1 antibody form, as well as multiple conjugated forms of anti-HPA1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heparanases (HPA) degrade heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix and play animportant role in the extravasation of blood-borne tumor cells and inflammatory leukocytes. HPA1 dismantles the subendothelial basal membrane and facilitates the metastasis of blood-borne tumor cells. Furthermore, HPA1 induces angiogenesis and likely promotes the vascularization of tumors. Upon degradation, HPAs free growth factors and cytokines that stimulate cell proliferation and chemotaxis. Fibroblasts endocytose extracellular HPA1 for cytoplasmic accumulation in vitro. Proteolytic processing at the cell surface of a precursor begets an active form of HPA1. The gene encoding human HPA1 maps to chromosome 4q21.3 .
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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