You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Hinokitol, an iron chelator originally extracted from woods of Thuja plicata and Chamaecyparis obtuse, has been found to inhibit ultraviolet B-induced apoptosis in keratinocytes of murine ear skin via antioxidant activity of metallothionein. Additionally, this compound has been found to also cause apoptotic cell death and cell cycle arrest of proliferating F9 cells via iron deprivation, resulting in an arrest at the G1-S interface or S phase. Antimicrobial activity has also been displayed by Hinokitiol through CPA (carboxypeptidase A) inhibition. Other studies have reported Hinokitiol to inhibit melanin synthesis by reducing protein levels of microphthalmia-associated transcription factor (MITF) and of Tyrosinase, a rate limiting melanogenic enzyme. Hinokitiol is an inhibitor of 12-LO.
1. Baba, T., et al. 1998. J. Invest. Dermatol.110: 24-28. PMID: 9424082
2. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22: 990-993. PMID: 10513629
3. Tanaka, T., et al. 1999. Cell Biol. Int. 23: 541-550. PMID: 10704238
4. Kim, D.S., et al. 2004. Arch. Pharm. Res. 27: 334-339. PMID: 15089040
산타크루즈바이오테크놀러지는 생물의학연구에 필요한 제품을 개발하는 선구자입니다. Toll Free 1-800-457-3801로 연락주세요. Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. 판권소유. "Santa Cruz Biotechnology", 와 Santa Cruz Biotechnology, Inc. 로고, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", 및 San Juan Ranch 로고, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz"와 "EZ Touch" 는 Santa Cruz Biotechnology, Inc의 등록된 상표입니다. 모든 상표는 각자 소유주의 소유입니다.