Hinokitiol CAS: 499-44-5
MF: C10H12O2
MW: 164.2
An apoptosis inducer and potent metal chelator.

Hinokitiol (CAS 499-44-5)

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Synonym: 4-Isopropyltropolone
Application An apoptosis inducer and potent metal chelator
CAS 등록번호: 499-44-5
순도: ≥98%
분자량: 164.2
분자식: C10H12O2
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Hinokitol, an iron chelator originally extracted from woods of Thuja plicata and Chamaecyparis obtuse, has been found to inhibit ultraviolet B-induced apoptosis in keratinocytes of murine ear skin via antioxidant activity of metallothionein. Additionally, this compound has been found to also cause apoptotic cell death and cell cycle arrest of proliferating F9 cells via iron deprivation, resulting in an arrest at the G1-S interface or S phase. Antimicrobial activity has also been displayed by Hinokitiol through CPA (carboxypeptidase A) inhibition. Other studies have reported Hinokitiol to inhibit melanin synthesis by reducing protein levels of microphthalmia-associated transcription factor (MITF) and of Tyrosinase, a rate limiting melanogenic enzyme. Hinokitiol is an inhibitor of 12-LO.


References

1. Baba, T., et al. 1998. J. Invest. Dermatol.110: 24-28. PMID: 9424082
2. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22: 990-993. PMID: 10513629
3. Tanaka, T., et al. 1999. Cell Biol. Int. 23: 541-550. PMID: 10704238
4. Kim, D.S., et al. 2004. Arch. Pharm. Res. 27: 334-339. PMID: 15089040

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in DMSO (up to 25 mg/ml), water (up to 25 mg/ml), ethanol, and ether.
저장 :
Store at room temperature
녹는점 :
≥ 260° C (lit.)
비등점 :
140° C (lit.) at 10 mmHg
밀도 :
1.13 g/cm3
굴절률 :
1.553
IC50 :
Tyrosinase: IC50 = 90 nM (Agaricus bisporus ); BRCA1-associated RING domain protein 1: IC50 = 3890 nM (human); FM3A (Breast carcinoma cells): IC50 = 1100 nM (Mus musculus); p53-binding protein Mdm-2: IC50 = 3580 nM (human)
Ki 데이타 :
Tyrosinase : Ki= 60 nM (Agaricus bisporus)
pK Values :
pKa: 7.06
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
GU4200000
PubChem CID :
3611
Merck Index :
14: 9390
MDL Number :
MFCD00040180
EC Number :
207-880-7
SMILES :
CC(C)C1=CC=CC(=O)C(O)=C1

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