Hep A VP3 Antibody (5E306): sc-71234

Hep A VP3 Antibody (5E306) is a mouse monoclonal IgG1 antibody that detects Hep A VP3 protein of Hep A origin by immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Anti-Hep A VP3 antibody (5E306) is available as the non-conjugated format. Hep A VP3 (Hep A virion protein 3) is a crucial capsid protein that plays a significant role in the virus′s life cycle, being involved in the assembly and stability of the viral capsid. Hep A VP3 contains an amino terminal T cell epitope, which is essential for eliciting an immune response, and couples to liposomes, enhancing potential as a target for vaccine development. The Hepatitis A virus, an enterovirus responsible for causing liver inflammation, is primarily transmitted through the orofecal route, often via contaminated food, leading to acute hepatitis. Symptoms of Hepatitis A can include jaundice, dark urine, nausea, fever, fatigue, loss of appetite, stomach ache, and vomiting, although only about 75% of infected individuals exhibit symptoms. Hep A infection typically does not result in permanent liver damage, making Hep A VP3 protein and its interactions vital for developing effective therapeutic strategies and vaccines.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Hep A VP3 Antibody (5E306) References:

1. Pathologic features of chronic hepatitis. A review and update.  |  Ishak, KG. 2000. Am J Clin Pathol. 113: 40-55. PMID: 10631857
2. Hepatitis C: an epidemiological review.  |  Memon, MI. and Memon, MA. 2002. J Viral Hepat. 9: 84-100. PMID: 11876790
3. Hepatitis A virus VP3 may activate serum response element associated transcription.  |  Kanda, T., et al. 2003. Scand J Gastroenterol. 38: 307-13. PMID: 12737447
4. Evidence of recombination in natural populations of hepatitis A virus.  |  Costa-Mattioli, M., et al. 2003. Virology. 311: 51-9. PMID: 12832202
5. Evidence for quasispecies distributions in the human hepatitis A virus genome.  |  Sánchez, G., et al. 2003. Virology. 315: 34-42. PMID: 14592757
6. The covalent coupling of HAV-VP3 (110-121) synthetic peptide to liposomes: physicochemical studies.  |  Muñoz, M., et al. 2004. Int J Pharm. 269: 177-84. PMID: 14698589
7. A novel CD4+ T-helper lymphocyte epitope in the VP3 protein of hepatitis A virus.  |  Sánchez, G., et al. 2004. J Med Virol. 72: 525-32. PMID: 14981753
8. [Duration of viremia and fecal shedding of the virus in hepatitis A infected children].  |  Munné, MS., et al. 2006. Acta Gastroenterol Latinoam. 36: 182-9. PMID: 17225445
9. Emerging need for vaccination against hepatitis A virus in patients with chronic liver disease in Korea.  |  Song, HJ., et al. 2007. J Korean Med Sci. 22: 218-22. PMID: 17449927
10. Synthesis, lipophilic derivatization and interaction with liposomes of HAV-VP3 (102-121) sequence by using spectroscopic techniques.  |  Garcia, M., et al. 1996. Analyst. 121: 1583-8. PMID: 8952449
11. Conformational behavior of the HAV-VP3(110-121) peptidic sequence and synthetic analogs in membrane environments studied by CD and computational methods.  |  Pérez, JA., et al. 1998. Biopolymers. 45: 479-92. PMID: 9577229
12. Enhancement of the immunogenicity of a synthetic peptide bearing a VP3 epitope of hepatitis A virus.  |  Pintó, RM., et al. 1998. FEBS Lett. 438: 106-10. PMID: 9821968

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep A VP3 Antibody (5E306) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep A VP3 Antibody (5E306) Specifications

Alternate Product Name: Hep A VP3

Product Clone Name: 5E306

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Hep A VP3

Epitope Species: Hep A Virus

Product Reactivity/Detection: nuetralizing epitope of VP3

Species Reactivity/Detection: Hep A

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Hep A VP3 Antibody (5E306): N/A