HBED CAS: 35369-53-0
MF: C20H24N2O6•HCl
MW: 424.89
An iron chelator and hydroxyl radical inhibitor.

HBED (CAS 35369-53-0)

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Synonym: N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride
Application An iron chelator and hydroxyl radical inhibitor
CAS 등록번호: 35369-53-0
분자량: 424.89
분자식: C20H24N2O6•HCl
* 참조분석증명서대량의 측정 데이터(함수량포함).
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HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.


References

1. Hershko, C., et al. 1984. J. Lab. Clin. Med. 103: 337-346. PMID: 6699459
2. Rollet-Labelle, E., et al. 1998. Free Radic. Biol. Med. 24: 563-572. PMID: 9559868
3. Gozin, A., et al. 1998. Free Radic. Biol. Med. 25: 1021-1032. PMID: 9870555
4. Faller, B., et al. 2000. J. Med. Chem. 43: 1467-1475. PMID: 10780902
5. Samuni, A.M., et al. 2001. Free Radic. Biol. Med. 30: 170-177. PMID: 11163534

Physical State :
Solid
용해도 :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) at 40° C, and water (4 mg/ml) at 50° C (with vigorous agitation approximately 15 minutes).
저장 :
Store at room temperature
굴절률 :
n20D 1.65
pK Values :
pKa: 1.77, 8.03
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
66848913
MDL Number :
MFCD04113603
SMILES :
C1=CC=C(C(=C1)CN(CCN(CC2=CC=CC=C2O)CC(=O)O)CC(=O)O)O.Cl

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