FOXQ1 Antibody (F-4): sc-166263

FOXQ1 Antibody (F-4) is a mouse monoclonal IgG3 antibody that detects FOXQ1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXQ1 is a member of the FOX family of transcription factors, which are characterized by a unique winged-helix or forkhead domain that plays a crucial role in regulating gene expression during various biological processes. FOXQ1 is primarily located in the nucleus, where FOXQ1 influences the transcription of genes involved in development, metabolism, and immune response. Notably, FOXQ1 is essential during embryogenesis and exhibits a tissue-restricted expression pattern in adult tissues, including the stomach, trachea, bladder, and salivary glands. FOXQ1 dysregulation has been implicated in several cancers, including colorectal adenocarcinoma and lung carcinoma, highlighting FOXQ1′s importance in tumorigenesis. Additionally, FOXQ1 has been shown to interact with specific proteins that modulate FOXQ1 activity, further underscoring FOXQ1′s role in lymphocyte development and immune function. Anti-FOXQ1 antibody (F-4) is an invaluable tool for researchers studying the intricate mechanisms of gene regulation and the implications of FOXQ1 in various diseases.

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FOXQ1 Antibody (F-4) References:

1. FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis.  |  Mitchell, AV., et al. 2022. Nat Commun. 13: 6548. PMID: 36319643
2. FOXQ1 inhibits breast cancer ferroptosis and progression via the circ_0000643/miR-153/SLC7A11 axis.  |  Huang, X., et al. 2023. Exp Cell Res. 431: 113737. PMID: 37591453
3. FOXQ1 promotes pancreatic cancer cell proliferation, tumor stemness, invasion and metastasis through regulation of LDHA-mediated aerobic glycolysis.  |  Wu, C., et al. 2023. Cell Death Dis. 14: 699. PMID: 37875474
4. PARP1-stabilised FOXQ1 promotes ovarian cancer progression by activating the LAMB3/WNT/β-catenin signalling pathway.  |  Wu, J., et al. 2024. Oncogene. 43: 866-883. PMID: 38297082
5. FOXQ1 inhibits the progression of osteoarthritis by regulating pyroptosis.  |  Luo, Z., et al. 2024. Aging (Albany NY). 16: 5077-5090. PMID: 38503493
6. Foxq1 Promotes Alveolar Epithelial Cell Death through Tle1-mediated Inhibition of the NF-κB Signaling Pathway.  |  Zhu, X., et al. 2024. Am J Respir Cell Mol Biol. 71: 53-65. PMID: 38574238
7. Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma.  |  Liu, Y., et al. 2024. Cell Death Dis. 15: 395. PMID: 38839744
8. FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced acute kidney injury by targeting the CREB5/NF-κB signaling axis.  |  Zhao, Q., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167331. PMID: 38960057
9. Foxq1 activates CB2R with oleamide to alleviate POCD.  |  Wu, X., et al. 2025. Brain Pathol. 35: e13289. PMID: 39046224
10. The transcription factor FOXQ1 in cancer.  |  Koch, S. 2025. Cancer Metastasis Rev. 44: 22. PMID: 39777582

The preferred FOXQ1 antibody is FOXQ1 Antibody (C-9): sc-166265.