Exportin 5 Antibody (C-2): sc-514503
- Exportin 5 Antibody (C-2) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 44-62 near the N-terminus of Exportin 5 of human origin
- recommended for detection of Exportin 5 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Exportin 5 Antibody (C-2). This work is in progress.
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Exportin 5 Antibody (C-2) is a mouse monoclonal IgM antibody that detects Exportin 5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Exportin 5 plays a crucial role in the nuclear transport of RNA, specifically recognizing and transporting RNAs that contain minihelix motifs, which are essential for the proper export of various RNA species from the nucleus to the cytoplasm. This transport mechanism is vital for maintaining cellular function, as anti-Exportin 5 antibody (C-2) ensures that the necessary RNA molecules are available for protein synthesis and other cellular processes. Additionally, Exportin 5 is involved in the nuclear export of double-stranded RNA binding proteins, such as eEF1A and tRNA, which are critical for translation and gene expression regulation. The ability of Exportin 5 to facilitate the movement of these molecules underscores its importance in cellular homeostasis and response to stress, making Exportin 5 (C-2) antibody a significant tool for research in RNA biology and related fields.
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Exportin 5 Antibody (C-2) References:
- Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. | Brownawell, AM. and Macara, IG. 2002. J Cell Biol. 156: 53-64. PMID: 11777942
- Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. | Chen, T., et al. 2004. Mol Cell Biol. 24: 6608-19. PMID: 15254228
- Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. | Yi, R., et al. 2005. RNA. 11: 220-6. PMID: 15613540
- A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. | Melo, SA., et al. 2010. Cancer Cell. 18: 303-15. PMID: 20951941
- Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder. | Han, Y., et al. 2013. J Surg Oncol. 107: 201-5. PMID: 22766726
- Global microRNA elevation by inducible Exportin 5 regulates cell cycle entry. | Iwasaki, YW., et al. 2013. RNA. 19: 490-7. PMID: 23431327
- MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability. | Li, J., et al. 2014. Nucleic Acids Res. 42: 458-74. PMID: 24057215
- Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells. | Ott, CA., et al. 2016. Oncotarget. 7: 62292-62304. PMID: 27556702
- Overexpression of Exportin-5 Overrides the Inhibitory Effect of miRNAs Regulation Control and Stabilize Proteins via Posttranslation Modifications in Prostate Cancer. | Höti, N., et al. 2017. Neoplasia. 19: 817-829. PMID: 28881308
- Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis. | Nuovo, G., et al. 2018. Ann Diagn Pathol. 32: 10-16. PMID: 29414391
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exportin 5 Antibody (C-2) | sc-514503 | 200 µg/ml | $322.00 | |||
Exportin 5 (C-2) Neutralizing Peptide | sc-514503 P | 100 µg/0.5 ml | $69.00 |