Molecular structure of ETI, CAS Number: 13488-22-7
ETI (CAS 13488-22-7)
Application:
ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor
CAS Number:
13488-22-7
Purity:
≥98%
Molecular Weight:
300.44
Molecular Formula:
C20H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ETI, also known as 5,8,11-eicosatriynoic acid, demonstrates the ability to inhibit 5-LO (5-lipoxygenase) activity and halt biosynthesis of leukotriene C4 by mastocytoma cells. Studies suggest that ETI also reduces oxidative metabolism of arachidonic acid (sc-200770). ETI also displays anti-proliferative properties which result from 5-LO selective inhibition and cause a decrease in platelet-induced growth of fibroblast cells. ETI is an inhibitor of 12-LO, 15-LO and GST.
ETI (CAS 13488-22-7) References
- Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells. | Lee, KC., et al. 2001. Pharmacol Toxicol. 88: 20-6. PMID: 11169157
- Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. | Kanda, H., et al. 2001. Am J Hypertens. 14: 248-53. PMID: 11281236
- Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. | Hamid, YH., et al. 2005. Diabet Med. 22: 74-80. PMID: 15606695
- 12-Lipoxygenase products modulate calcium signals in vascular smooth muscle cells. | Saito, F., et al. 1992. Hypertension. 20: 138-43. PMID: 1639455
- Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase. | Berg, C., et al. 2006. Thromb Haemost. 96: 652-9. PMID: 17080223
- Human monocytes exposed to Biostim (RU 41740) alter lymphocyte mitogenesis: mechanisms of action. | Viland, H. and Blomgren, H. 1988. Int J Immunopharmacol. 10: 879-87. PMID: 2466802
- Synergistic enhancement of mitogen responses of human lymphocytes by inhibitors of cyclo-oxygenase and 5,8,11-eicosatriynoic acid, an inhibitor of 12-lipoxygenase and leukotriene biosynthesis. | Blomgren, H., et al. 1987. Int Arch Allergy Appl Immunol. 83: 247-55. PMID: 3110073
- Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. | Hammarström, S. 1977. Biochim Biophys Acta. 487: 517-9. PMID: 406933
- Inhibition of leukotriene C and leukotriene D biosynthesis. | Orning, L. and Hammarström, S. 1980. J Biol Chem. 255: 8023-6. PMID: 6106018
- Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets. | Salari, H., et al. 1984. Prostaglandins Leukot Med. 13: 53-60. PMID: 6424136
- Reactive oxygen species and not lipoxygenase products are required for mouse B-lymphocyte activation and differentiation. | Fedyk, ER. and Phipps, RP. 1994. Int J Immunopharmacol. 16: 533-46. PMID: 7928003
- Purification and partial characterization of lipoxygenase with dual catalytic activities from human term placenta. | Joseph, P., et al. 1993. Biochem J. 293 (Pt 1): 83-91. PMID: 8328975
- Platelet lipoxygenase inhibitors attenuate thrombin- and thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregation. | Nyby, MD., et al. 1996. J Pharmacol Exp Ther. 278: 503-9. PMID: 8768697
- Hydrogen peroxide relaxes porcine coronary arteries by stimulating BKCa channel activity. | Barlow, RS. and White, RE. 1998. Am J Physiol. 275: H1283-9. PMID: 9746477
Inhibitor of:
12-LO, 15-LO, 5-LO, and GST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ETI, 1 mg | sc-200762 | 1 mg | $85.00 | |||
ETI, 10 mg | sc-200762A | 10 mg | $611.00 |