E2F-3 Antibody (0.N.263): sc-71018
- E2F-3 Antibody (0.N.263) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against recombinant E2F-3 of human origin
- recommended for detection of E2F-3 of mouse, rat and human origin by WB and IP; non cross-reactive with other members of the E2F family
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2F-3 Antibody (0.N.263) for WB applications. These reagents are now offered in bundles with E2F-3 Antibody (0.N.263) (see ordering information below).
E2F-3 Antibody (0.N.263) is a mouse monoclonal IgG2a antibody that detects E2F-3 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). E2F-3 is a crucial member of the E2F family of transcription factors, which play a significant role in regulating the cell cycle, particularly the transition from G1 phase to S phase. Anti-E2F-3 antibody (0.N.263) enables research into proper cell proliferation and differentiation, as dysregulation of E2F-3 can lead to uncontrolled cell growth and is often implicated in various cancers. E2F-3 functions by forming heterodimers with DP-1 protein, creating an active transcriptional regulatory complex that binds to specific DNA sequences to activate or repress target genes involved in cell cycle progression. Precise control of E2F-3 activity is essential, as overexpression or aberrant activation can disrupt normal cell cycle regulation, contributing to tumorigenesis. E2F-3 monoclonal antibody (0.N.263) serves as an invaluable tool for researchers studying mechanisms of cell cycle regulation and implications of E2F-3 in cancer biology.
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E2F-3 Antibody (0.N.263) References:
- E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. | Timmers, C., et al. 2007. Mol Cell Biol. 27: 65-78. PMID: 17167174
- Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14. | Kaitu'u-Lino, TJ., et al. 2015. Placenta. 36: 932-7. PMID: 26145228
- Determination of the physiological and pathological roles of E2F3 in adult tissues. | Gamper, I., et al. 2017. Sci Rep. 7: 9932. PMID: 28855541
- Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3. | Wang, Y., et al. 2021. Dig Dis Sci. 66: 4302-4313. PMID: 33386518
- MiR-573 suppresses cell proliferation, migration and invasion via regulation of E2F3 in pancreatic cancer. | Pengcheng, Z., et al. 2021. J Cancer. 12: 3033-3044. PMID: 33854603
- lncRNA SNHG22 sponges miR‑128‑3p to promote the progression of colorectal cancer by upregulating E2F3. | Yao, J., et al. 2021. Int J Oncol. 59: PMID: 34368861
- E2F3 promotes liver cancer progression under the regulation of circ-PRKAR1B. | Liu, G., et al. 2021. Mol Ther Nucleic Acids. 26: 104-113. PMID: 34513297
- E2F3 gene expression is a potential negative prognostic marker for localised and MYCN not-amplified neuroblastoma: Results of in silico analysis of 786 samples. | Ognibene, M., et al. 2022. Pediatr Blood Cancer. 69: e29800. PMID: 35652628
- LncRNA SPINT1-AS1/miR-433-3p/E2F3 positive feedback loop promotes the KRAS-mutant colorectal cancer cell proliferation, migration and invasion. | Sui, X., et al. 2022. Pathol Res Pract. 239: 154064. PMID: 36274378
- Long noncoding RNA POU6F2-AS2 contributes to the aggressiveness of nonsmall-cell lung cancer via microRNA-125b-5p-mediated E2F3 upregulation. | Yang, H., et al. 2023. Aging (Albany NY). 15: 2689-2704. PMID: 37053020
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-3 Antibody (0.N.263) | sc-71018 | 200 µg/ml | $322.00 | |||
E2F-3 Antibody (0.N.263): m-IgG Fc BP-HRP Bundle | sc-537199 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-3 Antibody (0.N.263): m-IgGκ BP-HRP Bundle | sc-534407 | 200 µg Ab; 40 µg BP | $361.00 |