안티-DSCR 1 항체 (G-2)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 DSCR 1 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-DSCR 1 항체 (G-2)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgGκ BP-HRP is the preferred secondary detection reagent for DSCR 1 Antibody (G-2) for WB applications. This reagent is now offered in a bundle with DSCR 1 Antibody (G-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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DSCR 1 Antibody (G-2) is a high quality monoclonal DSCR 1 antibody (also designated DSCR 1 antibody) suitable for the detection of the DSCR 1 protein of mouse, rat and human origin. DSCR 1 Antibody (G-2) is available as both the non-conjugated anti-DSCR 1 antibody form, as well as multiple conjugated forms of anti-DSCR 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. DSCR1 (Down syndrome critical region 1), also known as Calcipressin-1, Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer′s disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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