DNA-PKCS Antibody (6): sc-135886
- DNA-PKCS Antibody (6) is a mouse monoclonal IgG2a, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 874-1024 of DNA-PKCS of human origin
- recommended for detection of DNA-PKCS of human origin by WB, IP and IF; not recommended for IP
- See DNA-PKCS (G-12): sc-390849 for DNA-PKCS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DNA-PKCS Antibody (6). This work is in progress.
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DNA-PKCS Antibody (6) is a mouse monoclonal IgG2a antibody that detects DNA-PKCS in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). DNA-PKCS, a critical component of the DNA-dependent protein kinase complex, plays a vital role in the repair of double-strand breaks (DSBs) in DNA, which is essential for maintaining genomic stability and preventing cancer. Anti-DNA-PKCS antibody (6) targets a protein primarily located in the nucleus, where DNA-PKCS is involved in the non-homologous end joining (NHEJ) pathway, a key mechanism for repairing DSBs that can arise from various sources, including ionizing radiation and oxidative stress. DNA-PKCS monoclonal antibody (6) recognizes a protein crucial for normal cellular function, as defects in DNA-PKCS can lead to severe consequences, such as impaired DNA repair, increased sensitivity to DNA-damaging agents, and a higher risk of developing malignancies. DNA-PKCS interacts with other proteins in the NHEJ pathway, including the Ku heterodimer, which is essential for the initial recognition and binding of DSBs, further underscoring the importance of DNA-PKCS in cellular responses to DNA damage. DNA-PKCS (6) antibody provides an invaluable tool for researchers studying DNA repair mechanisms and their implications in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA-PKCS Antibody (6) | sc-135886 | 50 µg/0.5 ml | $322.00 |