D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt MF: C6H12O21P5•5Na
MW: 690.0
A soluble second messenger.

D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt

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Application D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt is a soluble second messenger
분자량: 690.0
분자식: C6H12O21P55Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It can be interconverted with Ins(3,4,5,6)P4 by a 1-kinase/1-phosphatase cycle, as well as with Ins(1,4,5,6)P4 in a 3-kinase/3-phosphatase cycle. Ins(1,3,4,5,6)P5 inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. It displays antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mices. Ins(1,3,4,5,6)P5 binds to the PH domain of Grp1.


References

1 Vivanco, I., Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nature Reviews Cancer 2 489-501 (2002). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 4 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 5 Piccolo, E., Vignati, S., Maffucci, T., et al. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene 23 1754-1765 (2004). 6 Maffucci, T., Piccolo, E., Cumashi, A., et al. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Res 65(18) 8339-8349 (2005). 7 Kavran, J.M., Klein, D.E., Lee, A., et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273(46) 30497-30508 (1998).

Appearance :
Lyophilized powder
Physical State :
Solid
저장 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
[Na+].[Na+].[Na+].[Na+].[Na+].O[[email protected]@H]1[[email protected]](OP(=O)([O-])O)[[email protected]@H](OP(=O)([O-])O)[[email protected]](OP(=O)([O-])O)[[email protected]@H](OP(=O)([O-])O)[[email protected]@H]1OP(=O)([O-])O

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