D-myo-Inositol-1,2,3,5-tetraphosphate, sodium salt MF: C6H12O18P4•4Na
MW: 588.00
A soluble second messenger in the transmission of cellular signals.

D-myo-Inositol-1,2,3,5-tetraphosphate, sodium salt

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Alternate Names: 1,2,3,5-IP4 (sodium salt); Ins(1,2,3,5)-P4 (sodium salt)
Application D-myo-Inositol-1,2,3,5-tetraphosphate, sodium salt is a soluble second messenger in the transmission of cellular signals
순도: >98%
분자량: 588.00
분자식: C6H12O18P44Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol-1,2,3,5-tetraphosphate, sodium salt is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,3,5)P4 exhibits relatively weak agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells, where it induces Ca2+ mobilization with an ED50 value of 93.3 µM, making it nearly less effective than Ins(1,4,5)P3 in the same assay.


References

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 4 Burford, N.T., Nahorski, S.R., Chung, S., et al. Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor. Cell Calcium 21 301-310 (1997).

Appearance :
Lyophilized powder
Physical State :
Solid
저장 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53394604
SMILES :
O[[email protected]@H]1[[email protected]@H](OP([O-])(O)=O)[[email protected]](O)[[email protected]@H](OP([O-])(O)=O)[[email protected]@H](OP([O-])(O)=O)[[email protected]]1OP([O-])(O)=O.[Na+].[Na+].[Na+].[Na+]

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