Molecular structure of Cytostatin, CAS Number: 156856-30-3
Cytostatin (CAS 156856-30-3)
Alternate Names:
5,6-Dihydro-6-(6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl)-5-methyl-2H-pyran-2-one
Application:
Cytostatin is a cell adhesion inhibitor, antimetastatic agent, apoptosis inhibitor and PP2A inhibitor
CAS Number:
156856-30-3
Purity:
≥75%
Molecular Weight:
450.44
Molecular Formula:
C21H32NaO7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cytostatin is a cell adhesion inhibitor, inhibiting the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. It is also an antitumor agent (antimetastatic), apoptosis inducer, and potent and selective PP2A-C (protein phosphatase 2A) inhibitor. Cytostatin interferes with the tyrosine phosphorylation of focal adhesion proteins such as focal adhesion kinase (FAK) and paxillin, which are for cell adhesion to fibronectin, a component of the ECM. This selective inhibition of PP2A by cytostatin leads to increased intracellular serine/threonine-phosphorylated proteins, modifying cell adhesion dynamics and potentially contributing to its anti-metastatic effects.
Cytostatin (CAS 156856-30-3) References
- Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. | Kawada, M., et al. 1999. Biochim Biophys Acta. 1452: 209-17. PMID: 10559474
- Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells. | Kawada, M., et al. 2003. Int Immunopharmacol. 3: 179-88. PMID: 12586599
- Synthesis and biological evaluation of cytostatin analogues. | Bialy, L. and Waldmann, H. 2003. Chem Commun (Camb). 1872-3. PMID: 12932009
- Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. | Bialy, L. and Waldmann, H. 2004. Chemistry. 10: 2759-80. PMID: 15195307
- Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. | Lawhorn, BG., et al. 2006. J Am Chem Soc. 128: 16720-32. PMID: 17177422
- Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and(beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. | Swingle, MR., et al. 2009. J Pharmacol Exp Ther. 331: 45-53. PMID: 19592665
- Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin. | Bialy, L. and Waldmann, H. 2002. Angew Chem Int Ed Engl. 41: 1748-51. PMID: 19750704
- Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. | Wada, S., et al. 2010. Cancer Sci. 101: 743-50. PMID: 20028386
- Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden. | Kwon, WS., et al. 2018. Oncol Lett. 16: 5583-5590. PMID: 30344712
- The potent protein phosphatase 2A inhibitors aminocytostatins: new derivatives of cytostatin. | Tohyama, S., et al. 2021. J Antibiot (Tokyo). 74: 743-751. PMID: 34290381
- Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin. | Yamazaki, K., et al. 1995. J Antibiot (Tokyo). 48: 1138-40. PMID: 7490221
- Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells. | Masuda, T., et al. 1995. J Antibiot (Tokyo). 48: 528-9. PMID: 7622443
- Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities. | Amemiya, M., et al. 1994. J Antibiot (Tokyo). 47: 536-40. PMID: 8040050
Inhibitor of:
ACTG1, and PP2A-C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytostatin, 250 µg | sc-394496 | 250 µg | $459.00 |