cystatin S/SA/SN Antibody (Z8983): sc-73884

Cystatin S/SA/SN Antibody (Z8983) is a mouse monoclonal IgG2b antibody that detects cystatin S/SA/SN protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-cystatin S/SA/SN antibody (Z8983) is available as a non-conjugated format. Cystatin S, cystatin SA, and cystatin SN are crucial members of the cystatin superfamily, which consists of cysteine protease inhibitors that play significant roles in various biological processes. These proteins are primarily found in saliva, but cystatin S and SN can also be detected in tears, urine, and seminal fluid, highlighting their importance in maintaining protease balance in bodily fluids. The presence of these cystatins in saliva is particularly important as they help protect oral tissues from proteolytic damage, thereby contributing to oral health and preventing inflammation. Additionally, cystatin C, a related protein, is expressed in various tissues including the brain and thymus, and serves as a key regulator of proteolytic activity in those areas. The ability of cystatins to inhibit cysteine peptidases, such as cathepsins, underscores their role in modulating protein degradation and maintaining cellular homeostasis. Cystatin S/SA/SN (Z8983) monoclonal antibody is an essential tool for researchers studying the functions and interactions of these proteins in health and disease.

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cystatin S/SA/SN Antibody (Z8983) References:

1. Involvement of cystatin C in oxidative stress-induced apoptosis of cultured rat CNS neurons.  |  Nishio, C., et al. 2000. Brain Res. 873: 252-62. PMID: 10930551
2. Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping.  |  Janowski, R., et al. 2001. Nat Struct Biol. 8: 316-20. PMID: 11276250
3. Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.  |  Calero, M., et al. 2001. J Neurochem. 77: 628-37. PMID: 11299325
4. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.  |  Manoury, B., et al. 2001. Curr Biol. 11: 447-51. PMID: 11301256
5. Cystatin C is an independent predictor of fasting and post-methionine load total homocysteine concentrations among stable renal transplant recipients.  |  Aras O, ., et al. 2001. Clin Chem. 47: 1263-8. PMID: 11427458
6. Cystatins.  |  Abrahamson, M., et al. 2003. Biochem Soc Symp. 179-99. PMID: 14587292
7. Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.  |  Saitoh, E., et al. 1988. Biol Chem Hoppe Seyler. 369 Suppl: 191-7. PMID: 3202964

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cystatin S/SA/SN Antibody (Z8983) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-cystatin S/SA/SN Antibody (Z8983) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cystatin S/SA/SN Antibody (Z8983) Specifications

Alternate Product Name: cystatin S/SA/SN

Product Clone Name: Z8983

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 21-141

Epitope Target: cystatin SA/SN

Epitope Species: human

Product Reactivity/Detection: cystatin SA, S and SN

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for cystatin S/SA/SN Antibody (Z8983): N/A