CEP104 Antibody (G-11): sc-514475

CEP104 Antibody (G-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects CEP104 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CEP104 antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CEP104, also known as centrosomal protein 104kDa, KIAA0562, or GlyBP, is a 925 amino acid protein that plays a crucial role in the organization and function of the centrosome, which is essential for proper cell division and maintaining genomic stability. CEP104 localizes to the cytoplasm and is involved in the assembly of microtubules and regulation of cilia formation, both vital for cellular signaling and movement. CEP104 undergoes phosphorylation at serine residue 323, a modification that can influence activity and protein interactions. CEP104 exists as three alternatively spliced isoforms and is mapped to human chromosome 1, which is the largest chromosome in the human genome and is associated with numerous genetic disorders. Understanding CEP104 function and interactions is critical, as dysregulation of centrosomal proteins can lead to various diseases, including cancer and ciliopathies.

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CEP104 Antibody (G-11) References:

1. Lamin A-dependent nuclear defects in human aging.  |  Scaffidi, P. and Misteli, T. 2006. Science. 312: 1059-63. PMID: 16645051
2. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.  |  Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.  |  Jakobsen, L., et al. 2011. EMBO J. 30: 1520-35. PMID: 21399614
4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Nagase, T., et al. 1998. DNA Res. 5: 31-9. PMID: 9628581
5. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
6. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.  |  McClintock, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 2154-9. PMID: 16461887
7. Cell biology: ageing nucleus gets out of shape.  |  Lans, H. and Hoeijmakers, JH. 2006. Nature. 440: 32-4. PMID: 16511477
8. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEP104 Antibody (G-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CEP104 Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEP104 Antibody (G-11) Specifications

Alternate Product Name: CEP104

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 13-33

Epitope Target: CEP104

Epitope Species: human

Product Reactivity/Detection: CEP104

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CEP104 Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin