Cdc14a phosphatase Antibody (DCS-291): sc-56260

Cdc14a phosphatase Antibody (DCS-291) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cdc14a phosphatase of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Cdc14a phosphatase antibody (DCS-291) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cdc14a phosphatase plays a crucial role in cell cycle regulation, particularly in activating mitotic exit through dephosphorylation of specific cyclin-dependent kinase substrates. This process ensures proper chromosome segregation and genomic stability during cell division. Cdc14a phosphatase remains sequestered in the nucleolus until release during mitosis, highlighting a tightly regulated function. Cdc14a phosphatase interacts with key proteins such as tumor suppressor protein p53, influencing activity and potentially impacting cellular responses to stress and DNA damage. Through dephosphorylation of hCdh1 and activation of anaphase-promoting complex Cdh1, Cdc14a phosphatase demonstrates importance in regulating centrosome cycle, mitosis, and cytokinesis. Dysregulation of Cdc14a phosphatase can lead to significant cellular consequences, including impaired centrosome separation and chromosome segregation, which are critical for maintaining genomic integrity in human cells.

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Cdc14a phosphatase Antibody (DCS-291) References:

1. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene.  |  Wong, AK., et al. 1999. Genomics. 59: 248-51. PMID: 10409437
2. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.  |  Li, L., et al. 2000. J Biol Chem. 275: 2410-4. PMID: 10644693
3. Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a.  |  Bembenek, J. and Yu, H. 2001. J Biol Chem. 276: 48237-42. PMID: 11598127
4. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.  |  Mailand, N., et al. 2002. Nat Cell Biol. 4: 317-22. PMID: 11901424
5. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.  |  Kaiser, BK., et al. 2002. Mol Biol Cell. 13: 2289-300. PMID: 12134069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cdc14a phosphatase Antibody (DCS-291) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cdc14a phosphatase Antibody (DCS-291) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cdc14a phosphatase Antibody (DCS-291) Specifications

Alternate Product Name: Cdc14a phosphatase

Product Clone Name: DCS-291

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cdc14a phosphatase

Epitope Species: human

Product Reactivity/Detection: Cdc14a phosphatase

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cdc14a phosphatase Antibody (DCS-291): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin