CD45 Antibody (F10-89-4): sc-52490
- CD45 Antibody (F10-89-4) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against T lymphocytes of human origin
- recommended for detection of CD45 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD45 (35-Z6): sc-1178 for CD45 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD45 Antibody (F10-89-4) for WB and IHC(P) applications. These reagents are now offered in bundles with CD45 Antibody (F10-89-4) (see ordering information below).
CD45 Antibody (F10-89-4) is a mouse monoclonal IgG2a kappa light chain antibody developed to target CD45, also known as Protein Tyrosine Phosphatase Receptor Type C (PTPRC). CD45 is a crucial transmembrane glycoprotein expressed on the surface of all nucleated hematopoietic cells in humans, playing an essential role in regulating immune cell signaling and activation. Located on the cell membrane, CD45 facilitates critical signal transduction pathways by dephosphorylating key tyrosine residues on Src family kinases such as Lck and Fyn, as well as on Syk family kinases like ZAP-70. This strategic localization is vital for controlling T and B cell receptor signaling, thereby influencing lymphocyte development, activation, and overall immune responses. Anti-CD45 antibody (F10-89-4) is raised against T lymphocytes of human origin, ensuring effective detection in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD45 (F10-89-4) antibody recognizes multiple isoforms of CD45, which arise from alternative splicing of the CD45 gene, allowing for the identification and analysis of different immune cell subsets. Anti-CD45 antibody (F10-89-4) enables comprehensive studies of immune cell populations and their signaling mechanisms, making CD45 (F10-89-4) monoclonal antibody an indispensable tool for both research and diagnostic purposes in immunology and hematology. CD45 monoclonal antibody (F10-89-4)′s ability to detect various isoforms enhances research potential in understanding immune system dynamics and developing targeted therapies for immune-related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD45 Antibody (F10-89-4) | sc-52490 | 200 µg/ml | $322.00 | |||
CD45 Antibody (F10-89-4): m-IgG Fc BP-HRP Bundle | sc-536857 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD45 Antibody (F10-89-4): m-IgGκ BP-HRP Bundle | sc-534024 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD45 Antibody (F10-89-4): m-IgG2a BP-HRP Bundle | sc-547885 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD45 Antibody (F10-89-4) FITC | sc-52490 FITC | 200 µg/ml | $336.00 | |||
CD45 Antibody (F10-89-4) PE | sc-52490 PE | 200 µg/ml | $349.00 |