Molecular structure of Bosentan, CAS Number: 147536-97-8
Bosentan (CAS 147536-97-8)
See product citations (3)
Alternate Names:
Actelion
Application:
Bosentan is a mixed endothelin receptor antagonist
CAS Number:
147536-97-8
Purity:
≥98%
Molecular Weight:
551.61
Molecular Formula:
C27H29N5O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bosentan is a compound of interest in biochemical research due to its action on specific biological targets. Within research applications, Bosentan is utilized to study its binding and inhibitory action on endothelin receptors. It is a useful tool for exploring the pathophysiological implications of endothelin in various cellular systems. By inhibiting these receptors, Bosentan aids in the elucidation of the processes that control vasoconstriction and cell proliferation. Moreover, researchers use Bosentan as a reference in the development of assays to investigate endothelin receptor activity and in the synthesis of new compounds with similar or improved biological properties. It is also involved in research focusing on the molecular mechanisms of signal transduction in cardiovascular conditions.
Bosentan (CAS 147536-97-8) References
- Bosentan, a selective and more potent antagonist for Atractaspis envenomation than the specific antivenom. | Abd-Elsalam, MA. 2011. Toxicon. 57: 861-70. PMID: 21392521
- Using bosentan to treat paraquat poisoning-induced acute lung injury in rats. | Zhang, Z., et al. 2013. PLoS One. 8: e75943. PMID: 24155875
- Bosentan, a mixed endothelin receptor antagonist, induces antidepressant-like activity in mice. | Pinho-Ribeiro, FA., et al. 2014. Neurosci Lett. 560: 57-61. PMID: 24361136
- What is the role of bosentan in healing of femur fractures in a rat model? | Aydin, A., et al. 2015. J Bone Miner Metab. 33: 496-506. PMID: 25298328
- Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes. | Bogdanov, P., et al. 2018. Int J Mol Sci. 19: PMID: 30428543
- The effects of bosentan on hyperoxia-induced lung injury in neonatal rats. | Özdemir, ÖM., et al. 2019. Pediatr Int. 61: 1120-1126. PMID: 31560816
- Investigation of Bosentan's Effects on Pulmonary Contusion Created by Blunt Thoracic Trauma in Rats. | Gercel, G., et al. 2020. Eur J Pediatr Surg. 30: 71-78. PMID: 31600800
- The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21. | Xu, X., et al. 2019. Biomed Res Int. 2019: 8348430. PMID: 31886257
- Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension. | Yorifuji, K., et al. 2020. Can J Physiol Pharmacol. 98: 625-628. PMID: 32433892
- Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension. | Chaumais, MC., et al. 2021. Cardiovasc Res. 117: 1391-1401. PMID: 32653925
- Ameliorative role of bosentan, an endothelin receptor antagonist, against sodium arsenite-induced renal dysfunction in rats. | Sharma, AK., et al. 2021. Environ Sci Pollut Res Int. 28: 7180-7190. PMID: 33026618
- Effect of bosentan in pulmonary hypertension development in systemic sclerosis patients with digital ulcers. | Castellví, I., et al. 2020. PLoS One. 15: e0243651. PMID: 33301540
- Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy. | Koyama, S., et al. 2021. Drug Metab Dispos. 49: 298-304. PMID: 33558262
- The Influence of Bosentan on MicroRNA-27a/PPARγ/ET-1 Signaling Pathway in Pulmonary Artery Hypertension. | Zhao, H., et al. 2021. Pediatr Cardiol. 42: 1141-1148. PMID: 33856498
Inhibitor of:
ATP-binding cassette (ABC) transporter, BSEP, Dear, EG625716, ENT2, ETAR, ETBR, LF, NTCP, OATP-A, Oatp3, Oatp5, Olfr250, Olr1646, Olr413, rat endothelium, SPARC, TBX4, UST, and Vasculin.Activator of:
Adrenomedullin (ADM), CYP2D12, Dear, EG625716, ETAR, MRP7, Pael-R, and SMTNL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bosentan, 10 mg | sc-210957 | 10 mg | $195.00 |