Blood Group B Antigen Antibody (Z5H-2): sc-69952

Blood Group B Antigen Antibody (Z5H-2) is a mouse monoclonal IgM antibody that detects Blood Group B Antigen protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Blood Group B Antigen (Z5H-2) antibody is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing versatility for different experimental needs. Blood Group B Antigen plays a crucial role in the immune response, as a key component of the ABO blood group system, which is essential for blood transfusions and organ transplants. The presence or absence of Blood Group B Antigen on the surface of red blood cells determines an individual′s blood type, influencing compatibility in medical procedures. Blood Group B Antigen is a mucin-type glycoprotein, characterized by a carbohydrate-rich structure that can undergo various post-translational modifications, such as glycosylation. These modifications affect protein stability, recognition by antibodies, and interactions with other proteins, ultimately influencing immune responses and cellular signaling pathways. Understanding Blood Group B Antigen dynamics and modifications is vital for advancing transfusion medicine and developing targeted therapies for blood-related disorders.

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Blood Group B Antigen Antibody (Z5H-2) References:

1. Development of H activity by human blood-group B substance treated with coffee bean alpha-galactosidase.  |  WATKINS, WM., et al. 1962. Nature. 195: 1204-6. PMID: 14005253
2. Immuno-chemical studies on blood groups; the preparation of blood group A and B substances and an inactive substance from individual horse stomachs and of blood group B substance from human saliva.  |  BAER, H., et al. 1950. J Exp Med. 91: 105-14. PMID: 15395576
3. Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide.  |  Yi, W., et al. 2005. J Am Chem Soc. 127: 2040-1. PMID: 15713070
4. Bifidobacterial α-galactosidase with unique carbohydrate-binding module specifically acts on blood group B antigen.  |  Wakinaka, T., et al. 2013. Glycobiology. 23: 232-40. PMID: 23089618
5. Transient acquired blood group B antigen associated with diverticular bowel disease.  |  Roath, S., et al. 1987. Acta Haematol. 77: 188-90. PMID: 3113163
6. Blood group B antigen on renal endothelium as the target for rejection in an ABO-incompatible recipient.  |  Paul, LC., et al. 1978. Transplantation. 26: 268-71. PMID: 360529
7. Suppressed expression of blood group B antigen and blood group galactosyltransferase in a preleukemic subject.  |  Yoshida, A., et al. 1985. Blood. 66: 990-2. PMID: 3929862
8. Normal blood group B antigen and B transferase activity in a patient with IgM autoanti-B agglutinin.  |  Lopez, M., et al. 1978. Vox Sang. 34: 18-21. PMID: 414449
9. Blood group B antigen in cell cultures of rhesus monkey kidney.  |  Kano, K. 1966. Int Arch Allergy Appl Immunol. 30: 281-7. PMID: 4959218
10. Action of alpha-galactosidase from Clostridium sporogenes and coffee beans on blood group B antigen of erythrocytes. The effect on the viability of erythrocytes in circulation.  |  Dybus, S. and Aminoff, D. 1983. Transfusion. 23: 244-7. PMID: 6304953
11. Study of blood group B antigen with a specific monoclonal antibody (anti-B, b-183).  |  Rouger, P., et al. 1983. Immunology. 49: 77-82. PMID: 6840810
12. Expression of a blood group B antigen-related glycoepitope in human dorsal root ganglion cells.  |  Yamada, M., et al. 1994. J Neurol Sci. 126: 178-83. PMID: 7531759

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group B Antigen Antibody (Z5H-2) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group B Antigen Antibody (Z5H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group B Antigen Antibody (Z5H-2) Specifications

Alternate Product Name: Blood Group B Antigen

Product Clone Name: Z5H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Blood Group B Antigen

Epitope Species: human

Product Reactivity/Detection: Blood Group B Antigen

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Blood Group B Antigen Antibody (Z5H-2): N/A