Benazeprilat CAS: 86541-78-8
MF: C22H24N2O5
MW: 396.44
A potent ACE inhibitor.

Benazeprilat (CAS 86541-78-8)

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Alternate Names: USP Benazepril Related Compound C
Application Benazeprilat is a potent ACE inhibitor
CAS 등록번호: 86541-78-8
분자량: 396.44
분자식: C22H24N2O5
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Benazeprilat is the active metabolite of benazepril (sc-337551), formed after cleavage of the ester group. Benazeprilat is a potent inhibitor of angiotensin-converting enzyme (ACE). This prevents the conversion of angiotensin I to the vasoconstrictor angiotensin II.


References

1. Kitagawa, Hitoshi., et al., 2003. An angiotensin converting enzyme inhibitor, benazepril can be transformed to an active metabolite, benazeprilat, by the liver of dogs with ascitic pulmonary heartworm disease. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 65(6): 701-6. PMID: 12867730
2. Toutain, P L., et al., 2004. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors. Journal of veterinary pharmacology and therapeutics. 27(6): 515-25. PMID: 15601445
3. Wang, Xue-Ding., et al., 2007. Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection. Journal of pharmaceutical and biomedical analysis. 44(1): 224-30. PMID: 17289327

Physical State :
Solid
용해도 :
Soluble in DMSO.
저장 :
Store at -20° C
녹는점 :
254-256° C
비등점 :
~711.3° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.64 (Predicted)
Optical Activity :
α20/D -200.5°, c = 1 in 3% aqueous NH4OH
IC50 :
Angiotensin-converting enzyme: IC50 = 1.7 nM (European rabbit)
pK Values :
pKa: 2.17 (Predicted), pKb: 8.35 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
MDL Number :
MFCD08060091
SMILES :
C1CC2=CC=CC=C2N(C(=O)[[email protected]]1N[[email protected]@H](CCC3=CC=CC=C3)C(=O)O)CC(=O)O

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PMID: # 24863555  2014. J Pharm Biomed Anal. 98: 1-8.

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