BDP1 Antibody (B-7): sc-365123

BDP1 Antibody (B-7) is a mouse monoclonal IgG2a light chain antibody that detects BDP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BDP1, or brain-derived phosphatase 1, is a crucial member of the PEST protein tyrosine phosphatase family, playing a significant role in the regulation of protein tyrosine phosphorylation, which is essential for various cellular processes including cell growth, migration, and differentiation. BDP1 expression extends beyond the brain, as BDP1 is also found in the colon and several tumor-derived cell lines, indicating potential involvement in cancer biology. Notably, BDP1 has been shown to selectively dephosphorylate autophosphorylated tyrosine kinases such as Src and epidermal growth factor receptor (EGFR), which are often overexpressed in tumor tissues, thereby influencing signaling pathways that drive tumor progression. BDP1′s ability to modulate these critical kinases highlights BDP1′s importance in maintaining cellular homeostasis and potential as a therapeutic target in cancer treatment. Anti-BDP1 antibody (B-7) is an invaluable tool for researchers investigating the dynamics of protein phosphorylation and its implications in health and disease.

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BDP1 Antibody (B-7) References:

1. Mutational analysis of the transcription factor IIIB-DNA target of Ty3 retroelement integration.  |  Yieh, L., et al. 2002. J Biol Chem. 277: 25920-8. PMID: 11994300
2. The role of transcription initiation factor IIIB subunits in promoter opening probed by photochemical cross-linking.  |  Kassavetis, GA., et al. 2003. J Biol Chem. 278: 17912-7. PMID: 12637540
3. A gene-specific effect of an internal deletion in the Bdp1 subunit of the RNA polymerase III transcription initiation factor TFIIIB.  |  Ishiguro, A. and Kassavetis, GA. 2003. FEBS Lett. 548: 33-6. PMID: 12885403
4. TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.  |  Fairley, JA., et al. 2003. EMBO J. 22: 5841-50. PMID: 14592981
5. The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.  |  Zhong, S. and Johnson, DL. 2009. Proc Natl Acad Sci U S A. 106: 12682-7. PMID: 19620725
6. The TFIIF-like Rpc37/53 dimer lies at the center of a protein network to connect TFIIIC, Bdp1, and the RNA polymerase III active center.  |  Wu, CC., et al. 2011. Mol Cell Biol. 31: 2715-28. PMID: 21536656
7. Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits.  |  Chymkowitch, P. and Enserink, JM. 2018. Biochim Biophys Acta Gene Regul Mech. 1861: 310-319. PMID: 29127063
8. Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity.  |  Herrera, MC., et al. 2018. Nucleic Acids Res. 46: 11698-11711. PMID: 30247619
9. Blending Low-Frequency Vibrations and Push-Pull Effects Affords Superior Photoacoustic Imaging Agents.  |  Yu, L., et al. 2023. Angew Chem Int Ed Engl. 62: e202307797. PMID: 37336786
10. Characterization of the PEST family protein tyrosine phosphatase BDP1.  |  Kim, YW., et al. 1996. Oncogene. 13: 2275-9. PMID: 8950995

The preferred BDP1 antibody is BDP1 Antibody (B-6): sc-515058.