Date published: 2025-9-7

001 800-1338-3838

SCBT Portrait Logo
Seach Input

Bcl-2 항체 (C-2): sc-7382

4.6(141)
리뷰 쓰기질문하기

데이터 시트
  • Bcl-2 항체 C-2 는 마우스 monoclonal IgG1 κ Bcl-2 항체, 2,347간행물에 인용, 이며 200 µg/ml으로 제공합니다.
  • 아미노산에 대한 항체 1-205 중 human Bcl-2
  • Bcl-2 항체 (C-2)는 WB, IP, IF, IHC(P) and FCM으로 mouse, rat and human유래의 Bcl-2 를 감지하는 데에 추천한다.
  • 항-Bcl-2 항체(C-2)는 IP용 agarose와 결합되어 이용 가능하며, WB, IHC(P), ELISA용 HRP와 결합되어 이용 가능하며, IF, IHC(P), FCM용 phycoerythrin 또는 FITC와 결합되어 이용 가능합니다.
  • WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
  • WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
  • IF, IHC(P) 와 FCM에 사용가능한 TRITC or Alexa Fluor® 405 결합제품이 있습니다.
  • Bcl-2 (C-2): sc-7382무료10 µg 샘플을 신청하려면 기술지원팀 (또는 로컬 디스트리뷰터)에 연락주세요.
  • 1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP는 Bcl-2 항체 (C-2) WB 및 IHC(P) 애플리케이션용입니다. 이 시약은 이제 Bcl-2 항체 (C-2)와 함께 번들로 제공됩니다(아래 주문 정보 참조).

빠른 링크

더보기

Bcl-2 항체(C-2)는 웨스턴 블롯, 면역침전, 면역형광, 면역조직화학, 유세포분석 등을 통해 쥐, 쥐, 인간에서 유래된 Bcl-2 단백질을 검출하는 쥐 단일클론 IgG1 kappa 경쇄 항체입니다. Bcl-2 단일 클론 항체(C-2)는 비접합 형태와 아가로스, 과산화효소, 피코에리트린, 플루오레세인 이소티오시아네이트, 다중 알렉사 플루오르® 접합체를 포함한 다양한 접합 형태로 제공됩니다. Bcl-2 단백질은 정상적인 발달, 조직 항상성 유지, 병원체 방어에 필수적인 세포자멸사 조절의 핵심 역할을 담당합니다. 인간 조직의 면역염색 결과, Bcl-2는 주로 세포질에 국한되어 있으며 막과 관련되어 있어 항세포자멸성 종양 단백질로서의 기능을 강조합니다. Bcl-2는 항-세포사멸 단백질인 Bcl-xL, Mcl-1, Bcl-w, A1뿐만 아니라, 세포사멸 촉진 단백질인 Bax, Bak, Bik, Bad, Bid를 포함한 Bcl-2 계열의 다른 구성원들과 단백질-단백질 상호작용을 통해 세포 생존을 촉진합니다. Bcl-2의 항-세포자멸 기능의 조절은 단백질 분해 과정과 인산화 같은 메커니즘을 통해 이루어질 수 있으며, 이는 Bcl-2의 활동에 필수적입니다. 또한, Bcl-2는 미토콘드리아 막을 안정화시켜 사이토크롬 c/Apaf-1 경로의 활성화를 억제함으로써 세포자멸을 방지할 수 있습니다. Bcl-2 유전자의 돌연변이는 정상적인 세포 사멸 과정이 Bcl-2의 항-세포 사멸 효과의 과발현 또는 조절 장애로 인해 방해받는 다양한 암과 관련이 있습니다.

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

Alexa Fluor®는 미국 오리건주 Molecular Probes Inc.의 상표입니다.

LI-COR®와 Odyssey®는 LI-COR Biosciences의 등록 상표입니다.

Bcl-2 항체 (C-2) 참고문헌:

  1. 세포사멸 v-cyclin-CDK6 복합체는 Bcl-2를 인산화하고 비활성화합니다.  |  Ojala, PM., et al. 2000. Nat Cell Biol. 2: 819-25. PMID: 11056537
  2. 항암제 설계의 표적으로서의 Bcl-2 계열 단백질.  |  Huang, Z. 2000. Oncogene. 19: 6627-31. PMID: 11426648
  3. 과발현된 전장 인간 BCL2는 바쿨로바이러스에 감염된 Sf9 곤충 세포의 생존을 연장시킵니다.  |  Alnemri, ES., et al. 1992. Proc Natl Acad Sci U S A. 89: 7295-9. PMID: 1502141
  4. 무산소증 유발 세포 사멸에서 Bcl-2 패밀리 멤버의 역할.  |  Shroff, EH., et al. 2007. Cell Cycle. 6: 807-9. PMID: 17377500
  5. Bcl-2는 프로그램된 세포 사멸을 차단하는 미토콘드리아 막 내부 단백질입니다.  |  Hockenbery, D., et al. 1990. Nature. 348: 334-6. PMID: 2250705
  6. 세포 사멸: 조직 동역학에 광범위한 영향을 미치는 기본적인 생물학적 현상입니다.  |  Kerr, JF., et al. 1972. Br J Cancer. 26: 239-57. PMID: 4561027
  7. Bcl-2와 프로그램된 세포 사멸의 조절.  |  Reed, JC. 1994. J Cell Biol. 124: 1-6. PMID: 8294493
  8. Bcl-2에 의한 세포 사멸 방지: 미토콘드리아에서 사이토크롬 c의 방출이 차단됨.  |  Yang, J., et al. 1997. Science. 275: 1129-32. PMID: 9027314
  9. Bcl-2 단백질 계열: 세포 생존의 중재자.  |  Adams, JM. and Cory, S. 1998. Science. 281: 1322-6. PMID: 9735050

주문정보

제품명카탈로그 번호 단위가격수량관심품목

Bcl-2 항체 (C-2)

sc-7382
200 µg/ml
$316.00

Bcl-2 (C-2): m-IgGκ BP-HRP 번들

sc-520498
200 µg Ab, 40 µg BP
$354.00

Bcl-2 (C-2): m-IgG1 BP-HRP 번들

sc-533466
200 µg Ab; 20 µg BP
$354.00

Bcl-2 항체 (C-2) AC

sc-7382 AC
500 µg/ml, 25% agarose
$416.00

Bcl-2 항체 (C-2) HRP

sc-7382 HRP
200 µg/ml
$316.00

Bcl-2 항체 (C-2) FITC

sc-7382 FITC
200 µg/ml
$330.00

Bcl-2 항체 (C-2) PE

sc-7382 PE
200 µg/ml
$343.00

Bcl-2 항체 (C-2) Alexa Fluor® 488

sc-7382 AF488
200 µg/ml
$357.00

Bcl-2 항체 (C-2) Alexa Fluor® 546

sc-7382 AF546
200 µg/ml
$357.00

Bcl-2 항체 (C-2) Alexa Fluor® 594

sc-7382 AF594
200 µg/ml
$357.00

Bcl-2 항체 (C-2) Alexa Fluor® 647

sc-7382 AF647
200 µg/ml
$357.00

Bcl-2 항체 (C-2) Alexa Fluor® 680

sc-7382 AF680
200 µg/ml
$357.00

Bcl-2 항체 (C-2) Alexa Fluor® 790

sc-7382 AF790
200 µg/ml
$357.00

Bcl-2 항체 (C-2) B

sc-7382 B
200 µg/ml
$320.00

Bcl-2 항체 (C-2) TRITC

sc-7382 TRITC
200 µg/ml
$320.00

Bcl-2 항체 (C-2) Alexa Fluor® 405

sc-7382 AF405
200 µg/ml
$357.00

Dear, I am using your Bcl2 for immunofluorescence of mouse tissue. May I ask if there is a corresponding fluorescent secondary antibody available

Asked by: Tina1121
Thank you for your question. You can use the m-IgG κ BP-FITC, m-IgG κ BP-PE, m-IgG κ BP-CFL 488 and other fluorescent secondary antibodies. Thank you.
Answered by: Jiajun Z
Date published: 2023-06-05

Dear, I am interested in your antibody: anti-Bcl2 (c-2), ref sc-7382. Would it be possible to gel a small quantity of this product to try on my WB? Thank you for helping. Best wishes. Asta Valanciute

Asked by: Asta
Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Service
Date published: 2022-08-10

请问做免疫细胞化学(爬片),用哪种bcl-2?

Asked by: zzzhang
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Hello, do you know if this Anti-Bcl-2 polyclonal antibody (or any other) will work for Xenopus samples and/or for IP? Since a very big 1-205 aa sequence is mentioned as epitope I cannot actually blast to check for relevance. Thank you

Asked by: Alexpan2004
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-04-20

Hi, We're interested in cell death, including apoptosis and necrosis. And we want to get some preliminary data based on western blotting. Would you please recommend us some antibodies that would analyse cell deaths? Thanks, Ruizhi

Asked by: Ruizhi
Thank you for your question. There are so many proteins involved in apoptosis and necrosis that recommending specific proteins would not be possible for us to do without additional information. I suggest you take a look at necrosis and apoptosis marker proteins and decide on which ones you would like to study. Once you know which ones you want to look into, contact Technical Service again with your chosen protein targets and we're happy to help pick the best antibodies for those targets with you!
Answered by: Tech Service
Date published: 2019-11-12

请问这个抗体可以用于测试兔软骨的蛋白吗

Asked by: yall
Thank you for your question. This antibody has not yet been tested in rabbit and so that is not a recommended species at this time. We are still gathering data to show on our website. Check back for updates! 感谢您的提问。sc-7382还没有检测过兔子来源的样本,因此兔来源样本不是推荐检测的种属。
Answered by: Technical Support 9
Date published: 2019-10-23

Can I use this(monoclonal antibody against Bcl-2) mouse monoclonal antibody for immunohistochemical staining of swine(pig) tissue? Could you suggest me a suitable secondary antibody kit containing DAB chromogen?

Asked by: xgtian
Thank you for your question. We have not tested this antibody on swine or pig tissue, however, we are aware of a few publications citing use of this antibody in pig samples. For example, PMID: 19667935. We recommend using our ImmunoCruz® ABC Kit: sc-516216 , with our mouse IgG kappa binding protein (m-IgGκ BP) conjugated to biotin (B), m-IgGκ BP-B: sc-516142 . The secondary antibody is sold separately from the kit. Alternatively, you could use the directly conjugated primary antibody, Bcl-2 Antibody (C-2) HRP: sc-7382 HRP.
Answered by: Technical Support
Date published: 2019-07-13

Does this antibody recognizes both BCL2 isoforms?

Asked by: Mari Francis
Thank you for your question. We do not have any data regarding the reactivity of this antibody against the two different isoforms of Bcl-2. This mouse monoclonal antibody was raised against amino acids 1-205 of Bcl-2 of human origin, corresponding to isoform alpha (accession number P10415). The exact epitope recognized has not been determined. The beta isoform of Bcl-2 has been described as mapping at the C-terminus between amino acids 196-239.
Answered by: Technical Support
Date published: 2019-04-05
  • y_2025, m_8, d_27, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_20
  • loc_ko_KR, sid_7382, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 114ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Good antibodyUsed for Western blot, 1:1000, works well for the detection of endogenous and overexpressed BCL2.
Date published: 2025-08-21
Rated 5 out of 5 by from GoodGreat antibody for WB, works in mouse RAW 264.7 cells
Date published: 2025-03-18
Rated 5 out of 5 by from GoodIt's good to use. The band is clear and the backgroud is clean.
Date published: 2024-08-16
Rated 5 out of 5 by from Great features for western blotThe antibody can give a nice clean band. It is a good antibody.
Date published: 2024-07-05
Rated 3 out of 5 by from Resultado OptimoSe compro hace 3 meses y es funcional se tuvieron que ajustar las condiciones.
Date published: 2024-01-11
Rated 5 out of 5 by from Excellent functionalityI once used this antibody for Western blot experiments on mouse tumor tissue, and it worked very well
Date published: 2023-12-09
Rated 5 out of 5 by from GreatI use this antobody for Western Blot. I get a positive result. I would recommend this great antibody to my colleagues.
Date published: 2023-11-20
Rated 5 out of 5 by from Bcl-2 antibodyThe antibody is good at western blot. The band is clean and clear.
Date published: 2023-08-06
  • y_2025, m_8, d_27, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_141
  • loc_ko_KR, sid_7382, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
Bcl-2 항체 (C-2) is rated 4.6 out of 5 by 142.
  • y_2025, m_8, d_27, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_141
  • loc_ko_KR, sid_7382, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 104ms
  • REVIEWS, PRODUCT