Atorvastatin Lactone CAS: 125995-03-1
MF: C33H33FN2O4
MW: 540.62
An atorvastatin intermediate inhibitor of MAP and HMG-CoA.

Atorvastatin Lactone (CAS 125995-03-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 112ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Atorvastatin Lactone is rated 5.0 out of 5 by 3.
loading
5
3
4
0
3
0
2
0
1
0
Alternate Names: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide; Atorvastatin δ-Lactone
Application Atorvastatin Lactone is an atorvastatin intermediate inhibitor of MAP and HMG-CoA
CAS 등록번호: 125995-03-1
순도: ≥95%
분자량: 540.62
분자식: C33H33FN2O4
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

Atorvastatin Lactone is a metabolite of Atorvastin acid (sc-337542), which is an inhibitor of HMG-CoA reductase. By affecting Atorvastatin acid action, Atorvastatin Lactone prevents inhibition of P-glycoprotein mediated Rhodamine 123 (sc-208306) transport in cells. Studies suggest that Atorvastatin is also a potent scavenger for free radicals and prevents toxic effects of Gentamycin (sc-357362) by inhibiting NF-κB and MAPK signaling pathways.


References

1. Bogman, K., et al. 2001. Br. J. Pharmacol. 132: 1183-1192. PMID: 11250868
2. Ozbek, E., et al. 2009. Ren Fail. 31: 382-392. PMID: 19839839
3. Narwal, R., et al. 2010. Clin Pharmacokinet. 49: 693-702. PMID: 20818835

Physical State :
Solid
용해도 :
DMF, DMSO, ethyl acetate, methanol
저장 :
Store at -20° C
녹는점 :
103-106
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CC(C)C1=C(C(=C(N1CC[[email protected]@H]2C[[email protected]](CC(=O)O2)O)C3=CC=C(C=C3)F)C4=CC=CC=C4)C(=O)NC5=CC=CC=C5

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

Atorvastatin Lactone (CAS 125995-03-1)  논문정보

다른 사용자의 Atorvastatin Lactone (CAS 125995-03-1)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 2 of 2 합계

PMID: # 33341662  Shiozawa, A.|Yamaori, S.|Kamijo, S.|Ohmori, S.| et al. 2020. Drug Metab Pharmacokinet. 36: 100364.

PMID: # 24626400  Rodrigues, LR. et al. 2014. Analytica chimica acta. 818: 32-8.

인용 1 to 2 of 2 합계
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 95ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;