Molecular structure of ATM/ATR Kinase Inhibitor, CAS Number: 905973-89-9
ATM/ATR Kinase Inhibitor Inhibitor (CAS 905973-89-9)
See product citations (8)
Alternate Names:
CGK733
Application:
ATM/ATR Kinase Inhibitor is a cell-permeable compound that inhibits kinase activity of ATM / ATR
CAS Number:
905973-89-9
Purity:
≥95%
Molecular Weight:
555.84
Molecular Formula:
C23H18Cl3FN4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ATM/ATR Kinase Inhibitor is widely used in research that focuses on DNA damage response pathways. This compound serves as a tool for studying the roles of ATM and ATR kinases, which are key regulators of cellular responses to DNA damage, including the activation of repair mechanisms and cell cycle checkpoints. Researchers utilize ATM/ATR Kinase Inhibitor to investigate how inhibition of these kinases affects cell survival, DNA repair processes, and the maintenance of genomic stability. Additionally, the compound is employed in studies exploring the consequences of ATM and ATR inhibition on cancer cells, particularly in terms of sensitivity to DNA-damaging agents.
ATM/ATR Kinase Inhibitor Inhibitor (CAS 905973-89-9) References
- Small molecule-based reversible reprogramming of cellular lifespan. | Won, J., et al. 2006. Nat Chem Biol. 2: 369-74. PMID: 16767085
- Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling. | Goldstein, M., et al. 2008. Toxicol Appl Pharmacol. 229: 20-32. PMID: 18289623
- Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. | Cruet-Hennequart, S., et al. 2008. DNA Repair (Amst). 7: 582-96. PMID: 18289945
- Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. | Crescenzi, E., et al. 2008. Clin Cancer Res. 14: 1877-87. PMID: 18347191
- The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. | Alao, JP. and Sunnerhagen, P. 2009. Radiat Oncol. 4: 51. PMID: 19903334
- ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating. | Takahashi, A., et al. 2010. J Radiat Res. 51: 417-22. PMID: 20448412
- CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells. | Choi, S., et al. 2011. DNA Repair (Amst). 10: 1000-1; author reply 1002. PMID: 21865098
- Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization. | Kuroda, S., et al. 2012. Acta Med Okayama. 66: 83-92. PMID: 22525466
- CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. | Wang, H., et al. 2012. Biochem Biophys Res Commun. 422: 103-8. PMID: 22564734
- PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death. | Wang, Y., et al. 2015. Oncotarget. 6: 25252-65. PMID: 26259235
- CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways. | Wang, Y., et al. 2015. Oncotarget. 6: 39692-701. PMID: 26486079
- Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation. | Yang, L., et al. 2015. Oncol Lett. 10: 2856-2864. PMID: 26722253
- Cantharidin Overcomes Imatinib Resistance by Depleting BCR-ABL in Chronic Myeloid Leukemia. | Sun, X., et al. 2016. Mol Cells. 39: 869-876. PMID: 27989101
- Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning. | Yang, Y., et al. 2021. Hum Exp Toxicol. 40: 1141-1152. PMID: 33501840
Inhibitor of:
δ-tubulin, 1600012F09Rik, 53BP1, 9930039A11Rik, APLF, Aprataxin, Atm, ATMIN, ATR, C10orf104, C1orf115, C7orf27, DNA pol θ, ELOF1, Etaa1, FAAP24, FILIA, GBDR1, HEI10, HELB, Histone H2AX, KIAA1370, MDC1, Mec1, NBS1, NSE1, NSE2, PALB2, PIERCE 1, Rab GAP1, Rab GAP1L, Rad50, RAD54L2, Rif1, RNF113A2, RNF148, RNF168, RNF8, Ruvbl2, SmarcAL1, SMC1β, Supervillin, TBL2, translin, TRIM64B, UBTD1, Vmn1r160, VPRBP, and XRCC3.Activator of:
ACP6, ASB-13, Axotrophin, Claspin, Etaa1, FBL12, FBL13, FGD1, FIGNL1, Hus1, Microcephalin, MND1, PHLDB1, Profilin-3, RAO, SNM1A, TIP120A, TopBP1, and UBE2S.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATM/ATR Kinase Inhibitor, 5 mg | sc-202964 | 5 mg | $106.00 |