Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Arkadia Antibody (1-KK14) is a high quality monoclonal Arkadia antibody (also designated Arkadia antibody) suitable for the detection of the Arkadia protein of human origin. Arkadia Antibody (1-KK14) is available as the non-conjugated anti-Arkadia antibody. Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. The early mammalian embryo is patterned by signals emanating from extraembryonic and embryonic signaling centers, most notably the anterior visceral endoderm (AVE) and the node, respectively. Nodal-related members of the transforming growth factor (TGF)-beta family regulate the induction of mesoderm, endoderm and mesendoderm. The different tissues form in response to the same signaling molecules, which may elicit differential responses through concentration-dependent effects, extracellular cofactors and antagonists, or factor potentiation (2,4). The nuclear protein Arkadia specifically potentiates the mesendoderm-inducing activity of a subset of TGF-beta family members and interacts with Nodal, which mediates the function of Arkadia in node induction. Arkadia functions within extraembryonic tissues and is required to induce the node as an essential modulator of the nodal signalling cascade. The human gene for arkadia maps to chromosome 15q21 and encodes a 441 amino acid protein. The murine gene for arkadia maps to chromosome 9 39.0 cM and encodes a 989 amino acid protein.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.