Aripiprazole CAS: 129722-12-9
MF: C23H27Cl2N3O2
MW: 448.39
A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity.

Aripiprazole (CAS 129722-12-9)

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Alternate Names: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Application Aripiprazole is a selective dopamine D2-receptor antagonist showing autoreceptor agonist activity
CAS 등록번호: 129722-12-9
순도: ≥98%
분자량: 448.39
분자식: C23H27Cl2N3O2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aripiprazole is an anti-psychotic selective D2DR (dopamine D2-receptor) antagonist with dopamine autoreceptor agonist activity. Aripiprazole is an activator of SR-1A.


References

Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),

Appearance :
Crystalline powder
Physical State :
Solid
용해도 :
Soluble in water (partly), methanol (1 mg/ml), DMSO (90 mg/ml at 25° C), ethanol (2 mg/ml), and acetic acid.
저장 :
Store at -20° C
녹는점 :
140° C
비등점 :
646.2° C at 760 mmHg
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.59 (Predicted)
IC50 :
D2DR: IC50 = 7.6 nM (human); HERG: IC50 = 630.96 nM (human); Mdr-1: IC50 = 780 nM (human); Histamine H1 receptor: IC50 = >3 µM (rat); MATE1: IC50 = 130 µM (human)
Ki 데이타 :
D2DR: Ki= 0.2 nM (human); Serotonin 1a (5-HT1a) receptor: Ki= 0.4 nM (rat); SR-2A: Ki= 0.8 nM (human); Dopamine D1 receptor: Ki= 0.8 nM (rat); D3DR: Ki= 3.3 nM (human)
pK Values :
pKb: 7.67 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
VC8275950
PubChem CID :
Merck Index :
14: 785
MDL Number :
MFCD00892072
SMILES :
C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl

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Aripiprazole (CAS 129722-12-9)  논문정보

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PMID: # 25449598  Brust, TF. et al. 2015. Biochem. Pharmacol. 93: 85-91.

PMID: # 25539635  Brust, TF. et al. 2015. J. Pharmacol. Exp. Ther. 352: 480-93.

PMID: # 29635397  J Chromatogr Sci. 510-517.

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