Anthrax LF Antibody (5F502.2): sc-52914

Anthrax LF Antibody (5F502.2) is a mouse monoclonal IgG1 antibody that detects the Anthrax LF protein of Bacillus anthracis origin by western blotting (WB). Anti-Anthrax LF antibody (5F502.2) is available as a non-conjugated format, specifically designed to target the lethal factor component of the anthrax toxin. The anthrax lethal factor plays a critical role in the pathogenicity of Bacillus anthracis by functioning as a zinc-dependent metalloprotease that cleaves mitogen-activated protein kinase kinase (MAPKK) enzymes within the MAPK signaling pathway. This cleavage disrupts essential cellular signaling processes, leading to an impaired immune response characterized by an overproduction of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β). The consequences of this disruption are severe, as this process can result in septic shock and death, particularly in hosts with compromised immune systems. Additionally, anthrax lethal factor targets endothelial cells, causing vascular leakage and contributing to hypovolemic shock, which underscores the importance of understanding anthrax lethal factor function in the context of anthrax infection. Anti-Anthrax LF antibody (5F502.2) specifically detects this protein, making this reagent an invaluable tool for researchers studying the mechanisms of anthrax pathogenesis and the development of potential therapeutic interventions.

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Anthrax LF Antibody (5F502.2) References:

1. The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores.  |  Welkos, S., et al. 2001. Microbiology (Reading). 147: 1677-1685. PMID: 11390699
2. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin.  |  Agrawal, A., et al. 2003. Nature. 424: 329-34. PMID: 12867985
3. Immune system paralysis by anthrax lethal toxin: the roles of innate and adaptive immunity.  |  Fukao, T. 2004. Lancet Infect Dis. 4: 166-70. PMID: 14998502
4. Anthrax lethal toxin: a weapon of multisystem destruction.  |  Agrawal, A. and Pulendran, B. 2004. Cell Mol Life Sci. 61: 2859-65. PMID: 15558214
5. Anthrax lethal toxin blocks MAPK kinase-dependent IL-2 production in CD4+ T cells.  |  Fang, H., et al. 2005. J Immunol. 174: 4966-71. PMID: 15814725
6. Anthrax lethal toxin has direct and potent inhibitory effects on B cell proliferation and immunoglobulin production.  |  Fang, H., et al. 2006. J Immunol. 176: 6155-61. PMID: 16670324
7. Anthrax toxins: A paradigm of bacterial immune suppression.  |  Baldari, CT., et al. 2006. Trends Immunol. 27: 434-40. PMID: 16861036
8. Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival.  |  Ribot, WJ., et al. 2006. Infect Immun. 74: 5029-34. PMID: 16926394
9. Bacillus anthracis: a multi-faceted role for anthrax lethal toxin in thwarting host immune defenses.  |  Xu, L. and Frucht, DM. 2007. Int J Biochem Cell Biol. 39: 20-4. PMID: 17008119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Anthrax LF Antibody (5F502.2) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Anthrax LF Antibody (5F502.2) Specifications

Alternate Product Name: Anthrax LF

Product Clone Name: 5F502.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 779-792

Epitope Target: Anthrax LF

Epitope Species: Bacillus anthracis

Product Reactivity/Detection: Anthrax LF

Species Reactivity/Detection: Bacillus Anthracis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Anthrax LF Antibody (5F502.2): N/A