Date published: 2025-9-8

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Amsacrine hydrochloride (CAS 54301-15-4)

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대체 이름:
4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride; m-AMSA
적용:
Amsacrine hydrochloride 은 DNA 토포이소머라제 II 의 억제제입니다.
CAS 등록번호:
54301-15-4
순도:
≥98%
분자량:
429.92
분자식:
C21H19N3O3S•HCl
추가 정보:
운송용 위험물로 분류되어 추가 배송료가 부과될 수 있습니다.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data.

빠른 링크

DNA 토포이소머라제 II를 억제합니다.


Amsacrine hydrochloride (CAS 54301-15-4) 참고자료

Davey, R.A., et al., The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro. Cancer Chemother. Pharmacol. 39, 424-430, (1997) Nelson, E.M., et al., Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc. Natl. Acad. Sci. USA 81, 1361-1365, (1984) Ferguson, L.R., , Application of fluorescence in situ hybridization to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine. Environ. Mol. Mutagen. 27, 255, (1996) Mosesso, P., et al., Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques. Mutagenesis 13, 39-43, (1998) Del Bino, G., et al., The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res. 195, 485-491, (1991) Negri, C., et al., Induction of apoptotic cell death by DNA topoisomerase II inhibitors. Biochimie 77, 893-899, (1995)

주문정보

제품명카탈로그 번호 단위가격수량관심품목

Amsacrine hydrochloride, 10 mg

sc-214540
10 mg
$232.00