Ah Receptor Antibody (L-15): sc-101104

Ah Receptor Antibody (L-15) is a mouse monoclonal IgG1 antibody that detects Ah Receptor in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ah Receptor plays a crucial role as a ligand-dependent transcription factor that mediates biological responses to toxic compounds like 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon binding with TCDD, Ah Receptor forms a complex with Ah Receptor nuclear translocator (Arnt), which is essential for translocation from cytoplasm to nucleus. This translocation allows the complex to bind to specific DNA sequences known as xenobiotic responsive elements (XREs), thereby regulating the expression of genes induced by TCDD. The structural integrity of Ah Receptor, which includes a basic helix-loop-helix motif and a common "PAS" motif, is vital for function, as these motifs facilitate receptor interaction with Arnt and subsequent binding to XREs. Understanding the dynamics of Ah Receptor and its interactions is important for elucidating mechanisms of toxicity and potential health impacts of environmental pollutants. Anti-Ah Receptor antibody (L-15) is an invaluable tool for researchers studying these pathways and their implications in various biological contexts.

The preferred Ah Receptor antibody is Ah Receptor Antibody (A-3): sc-133088.