AdoMetDC Antibody (B-9): sc-377230

AdoMetDC Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects AdoMetDC in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). AdoMetDC, or adenylmethionine decarboxylase 1, is a crucial enzyme in the polyamine biosynthesis pathway, consisting of 334 amino acids. AdoMetDC (B-9) antibody targets a protein that plays a vital role in cellular growth and proliferation by catalyzing the conversion of S-adenosyl-L-methionine into a key intermediate, which is essential for the synthesis of polyamines that regulate cell functions and contribute to tumor promotion. Notably, AdoMetDC is synthesized as an inactive proenzyme that undergoes self-maturation to produce two distinct subunits, α and β, which then assemble into an active heterotetramer. AdoMetDC activity is intricately regulated; putrescine stimulates both proenzyme processing and catalytic function, while iodoacetic acid can inhibit activity. The formation of a heterotetramer allows for precise regulation of enzymatic activity, which is critical for maintaining cellular homeostasis and responding to growth signals. Anti-AdoMetDC antibody (B-9) serves as an invaluable tool for researchers studying the dynamics of polyamine metabolism and its implications in various biological processes and diseases.

The preferred AdoMetDC antibody is AdoMetDC Antibody (E-6): sc-166970.