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Adenosine 5′-diphosphoribose sodium salt (CAS 68414-18-6)

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Alternate Names:
ADP-Ribose
Application:
Adenosine 5′-diphosphoribose sodium salt is a substrate used in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family
CAS Number:
68414-18-6
Purity:
≥93%
Molecular Weight:
559.32 (non-salt)
Molecular Formula:
C15H23N5O14P2•xNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Adenosine 5′-diphosphoribose sodium salt, a nucleotide, holds significance in numerous biochemical and physiological processes. It finds application in investigating signal transduction pathways, gene expression, and energy metabolism. Moreover, it aids in the study of cell cycle regulation, apoptosis, DNA repair, protein folding, and enzyme kinetics.


Adenosine 5′-diphosphoribose sodium salt (CAS 68414-18-6) References

  1. The role of the invariant glutamate 95 in the catalytic site of Complex I from Escherichia coli.  |  Euro, L., et al. 2009. Biochim Biophys Acta. 1787: 68-73. PMID: 19061856
  2. Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products.  |  Pashikanti, S., et al. 2010. Free Radic Biol Med. 48: 656-63. PMID: 19969069
  3. Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.  |  Senisterra, GA., et al. 2010. J Biomol Screen. 15: 314-20. PMID: 20150591
  4. TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.  |  Lee, CR., et al. 2013. J Neurosci. 33: 1157-68. PMID: 23325252
  5. α,β-meATP mimics the effects of the purinergic neurotransmitter in the human and rat colon.  |  Martínez-Cutillas, M., et al. 2014. Eur J Pharmacol. 740: 442-54. PMID: 24998877
  6. Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose.  |  Hibbs, JB., et al. 2016. Redox Biol. 8: 271-84. PMID: 26895212
  7. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.  |  Schuller, M., et al. 2017. ACS Chem Biol. 12: 2866-2874. PMID: 28991428
  8. Generation and Characterization of Recombinant Antibody-like ADP-Ribose Binding Proteins.  |  Gibson, BA., et al. 2017. Biochemistry. 56: 6305-6316. PMID: 29053245
  9. The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress.  |  Zou, L., et al. 2021. Front Mol Biosci. 8: 780865. PMID: 34950703
  10. A cycling assay for the determination of mono(adenosine-5'-diphosphoribose)-protein bound conjugate levels in mouse tissues.  |  He, C. 1986. Anal Biochem. 155: 188-92. PMID: 3717555
  11. Lithium, but not carbamazepine, potentiates hyperactivity induced by intra-accumbens cholera toxin.  |  Kofman, O., et al. 1998. Pharmacol Biochem Behav. 59: 191-200. PMID: 9443555

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Adenosine 5′-diphosphoribose sodium salt, 25 mg

sc-210762
25 mg
$107.00

Adenosine 5′-diphosphoribose sodium salt, 100 mg

sc-210762A
100 mg
$294.00

Adenosine 5′-diphosphoribose sodium salt, 500 mg

sc-210762B
500 mg
$1280.00