2-Hexynyl-5′-N-ethylcarboxamidoadenosine (CAS 141018-30-6)

건강 상태 :

Solid

용해도 :

Soluble in DMSO (100 mM), methanol, and water (100 mM).

저장 :

Store at 4° C

녹는점 :

180-182° C

비등점 :

691.34° C (Predicted)

밀도 :

~1.5 g/cm³ (Predicted)

굴절률 :

n²⁰_D 1.69 (Predicted)

IC50 :

Adenosine A1 receptor: EC₅₀50 = >1 nM (rat); Superoxide anion production: EC₅₀50 = 3.63 nM; cAMP accumulation: EC₅₀50 = 43 nM; Adenosine A2 receptor: EC₅₀50 = 105 nM (human); Adenosine A1 receptor: IC₅₀ = 4.38 µM (rat)

Ki 데이타 :

Adenosine A2a receptor: K_i= 2.2 nM (rat); Adenosine A2 receptor: K_i= 2.2 nM (rat); Adenosine A2 receptor: K_i= 5.7 nM (human); Adenosine A3 receptor: K_i= 25.6 nM (rat); Adenosine A1 receptor: K_i= 43.9 nM (rat)

pK 값 :

pK_a: 12.89 (Predicted), pK_b: 2.33 (Predicted)

PubChem CID :

MDL 번호 :

MFCD03095611

SMILES :

CCCCC#CC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)C(=O)NCC)O)O