2-Furoyl-LIGRLO-amide trifluoroacetate salt CAS: 729589-58-6 (non-salt)
MF: C36H63N11O8 xC2HF3O2
MW: 777.95 (free base)
A potent, selective PAR2 agonist.

2-Furoyl-LIGRLO-amide trifluoroacetate salt (CAS 729589-58-6 (non-salt))

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2-Furoyl-LIGRLO-amide trifluoroacetate salt is rated 5.0 out of 5 by 1.
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Alternate Names: 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt; 2-fAP; 2-Fly
Application 2-Furoyl-LIGRLO-amide trifluoroacetate salt is a potent, selective PAR2 agonist
CAS 등록번호: 729589-58-6 (non-salt)
분자량: 777.95 (free base)
분자식: C36H63N11O8 xC2HF3O2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed, increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation.


References

Gardell, L.R., et al., Identification and characterization of novel small molecule protease activated receptor 2 (PAR2) agonists. J. Pharmacol. Exp. Ther., (2008); Hollenberg, M.D., et al., Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. J. Pharmacol. Exp. Ther. 326, 453-462, (2008); Niu, Q.X., et al., Induction of inflammatory cytokine release from human umbilical vein endothelial cells by agonists of proteinase-activated receptor-2. Clin. Exp. Pharmacol. Physiol. 35, 89-96, (2008)

Appearance :
Lyophilized powder
Physical State :
Solid
용해도 :
Soluble in water (>2 mg/ml).
저장 :
Store at -20° C
굴절률 :
n20D 1.61 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
MDL Number :
MFCD03821022

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