1,2,3,4,5,6-HEXABROMOCYCLOHEXANE CAS: 1837-91-8
MF: C6H6Br6
MW: 557.5
A potent and specific inhibitor of JAK2 autophosphorylation.

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE (CAS 1837-91-8)

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Alternate Names: JAK2 Inhibitor II
Application 1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation
CAS 등록번호: 1837-91-8
순도: >97%
분자량: 557.5
분자식: C6H6Br6
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* 참조분석증명서대량의 측정 데이터(함수량포함).
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1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. In silico simulation indicates that 1,2,3,4,5,6-Hexabromocyclohexane accesses a binding pocket positioned adjacent to the activation loop on the JAK2 protein. Growth hormone-mediated JAK2 autophosphorylation was greatly reduced by 1,2,3,4,5,6-Hexabromocyclohexane, and it was shown to not block autophosphorylation of the epidermal growth factor receptor.


References

1. Sandberg, E.M., et al. 2005. J. Med. Chem. 48: 2526-2533. PMID: 15801842

Physical State :
Solid
용해도 :
Soluble in DMSO (5 mg/ml).
저장 :
Store at 4° C
녹는점 :
218-223° C
비등점 :
388.88° C at 760 mmHg (Predicted)
밀도 :
2.90 g/cm3 (Predicted)
굴절률 :
n20D 1.70 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
MDL Number :
MFCD00059127
EC Number :
250-052-5
SMILES :
C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br

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