Vialinin A CAS: 858134-23-3
MF: C34H26O8
MW: 562.57
A potent inhibitor of the release of TNF-a.

Vialinin A (CAS 858134-23-3)

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別名: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
アプリケーション: Vialinin A is a potent inhibitor of the release of TNF-a
CAS 番号: 858134-23-3
Molecular Weight: 562.57
Molecular Formula: C34H26O8
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* Refer to Certificate of Analysis for lot specific data (including water content).

Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. Terphenyls, in general, are recognized as strong antioxidants. Vialinin A potently inhibits the release of TNF-α (IC50 = 0.09 nM) and IL-4 (IC50 = 2.8 nM), as well as β-hexosaminidase and CCL2 (MCP-1) from IgE-stimulated RBL-2H3 mast cells. Vialinin A does not significantly increase lactate dehydrogenase release from RBL-2H3 mast cells, suggesting low cytotoxicity.


参考文献

1 Radulovic, N., Quang, D.N., Hashimoto, T., et al. Terrestrins A-G: P-teraphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochem 66 1052-1059 (2005). 2 Xie, C., Koshino, H., Esumi, Y., et al. Vialinin A, a novel 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger from an edible mushroom in china. Biosci Biotech Biochem 69(12) 2326-2332 (2005). 3 Liu, J. Natural terphenyls: Developments since 1877. Chem Rev 106 2209-2223 (2006). 4 Onose, J., Xie, C., Ye, Y.Q., et al. Vialinin A, a novel potent inhibitor of TNF-a production from RBL-2H3 cells. Biol Pharm Bull 31(5) 831-833 (2008).

Physical State :
Solid
Solubility :
Soluble in ethanol (~10 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), DMSO:PBS(pH7.2)(1:3) (~0.25 mg/ml), and aqueous buffers (sparingly).
保存方法 :
Store at -20° C
Boiling Point :
~846.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Release of TNF-α: IC50 = 0.09 nM; Release of IL-4: IC50 = 2.8 nM
pK Values :
pKa: 7.81 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
MDL Number :
MFCD11113135
SMILES :
C1=CC=C(C=C1)CC(=O)OC2=C(C(=C(C(=C2C3=CC=C(C=C3)O)O)O)C4=CC=C(C=C4)O)OC(=O)CC5=CC=CC=C5

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