TRP1 Antibody (G-9): sc-166857

TRP1 Antibody (G-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects TRP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TRP1 (G-9) antibody is available as non-conjugated format. TRP1, also known as tyrosinase-related protein 1, plays a crucial role in melanin biosynthesis, the pigment responsible for coloration in skin, hair, and eyes. Located in melanosomes of melanocytes, TRP1 is essential for proper melanin production pathway function, contributing to enzymatic processes that convert tyrosine into melanin. Defects in TRP1 can lead to pigmentation disorders, including various forms of albinism. TRP1 interacts with other key proteins involved in melanin synthesis, such as tyrosinase (TYR) and TRP2, forming a multi-enzyme complex that enhances enzyme stability and activity. TRP1 supports TYR catalytic function and ensures efficient melanin production, highlighting significance in maintaining normal pigmentation and protecting against UV radiation.

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TRP1 Antibody (G-9) References:

1. Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway.  |  Brough, GH., et al. 2001. FASEB J. 15: 1704-1710. PMID: 11481220
2. Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels.  |  Vaca, L. and Sampieri, A. 2002. J Biol Chem. 277: 42178-87. PMID: 12196518
3. Cloning and sequence analysis of the TRP1 gene encoding the phosphoribosyl anthranilate isomerase from Pichia anomala (strain K).  |  Friel, D., et al. 2003. Yeast. 20: 1331-7. PMID: 14663825
4. Organisation of the complex locus trp1 in the fission yeast Schizosaccharomyces pombe.  |  Thuriaux, P., et al. 1982. Curr Genet. 6: 13-8. PMID: 24186364
5. An AT rich region of dyad symmetry is a promoter element in the yeast TRP1 gene.  |  Kim, SY., et al. 1988. Mol Gen Genet. 211: 472-6. PMID: 2835633
6. Quantitative Detection of Disseminated Melanoma Cells by Trp-1 Transcript Analysis Reveals Stochastic Distribution of Pulmonary Metastases.  |  Kyjacova, L., et al. 2021. J Clin Med. 10: PMID: 34830742
7. A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1).  |  Jiménez-Cervantes, C., et al. 1994. J Biol Chem. 269: 17993-8000. PMID: 8027058
8. Identification of four trp1 gene variants murine pancreatic beta-cells.  |  Sakura, H. and Ashcroft, FM. 1997. Diabetologia. 40: 528-32. PMID: 9165220
9. Store-operated calcium entry promotes shape change in pulmonary endothelial cells expressing Trp1.  |  Moore, TM., et al. 1998. Am J Physiol. 275: L574-82. PMID: 9728053
10. Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma.  |  Jiménez-Cervantes, C., et al. 1998. Biochem Biophys Res Commun. 253: 761-7. PMID: 9918801

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRP1 Antibody (G-9) has 40 citations in a variety of scientific publications.

Primary antibodies like Anti-TRP1 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRP1 Antibody (G-9) Specifications

Alternate Product Name: TRP1

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 448-537

Epitope Target: TRP1

Epitope Species: human

Product Reactivity/Detection: TRP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 40 citations in various scientific publications

Available Conjugates/Forms for TRP1 Antibody (G-9): N/A

The preferred TRP1 antibody is TRP1 Antibody (TA99): sc-58438.