Trolox CAS: 53188-07-1
MF: C14H18O4
MW: 250.29
An antioxidant derived from water-soluble vitamin E.

Trolox (CAS 53188-07-1)

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同義語 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
アプリケーション: An antioxidant derived from water-soluble vitamin E
CAS 番号: 53188-07-1
Purity: ≥97%
Molecular Weight: 250.29
Molecular Formula: C14H18O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid (sc-204753) and p-coumaric acid (sc-215648). Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii.


参考文献

1. Pannala, A.S., et al. 1998. Free Radic. Biol. Med. 24: 594-606. PMID: 9559872

2. Brookes, P.S., et al. 1998. J. Neurochem. 70: 2195-2202. PMID: 9572308

3. Chen, Q. and Cederbaum, A.I. 1998. Mol. Pharmacol. 53: 638-648. PMID: 9547353

4. Bian, X. et al. 2001. J. Biol. Chem. 276(52): 48921-48929. PMID: 11679590

5. Cuperus, R. et al. 2008. Int. J. Oncol. 32(5): 1011-1019. PMID: 18425327

6. Jung, M.Y. and Min, D.B. 2009. J. Food Sci. 74: C449-C455. PMID: 19723181

7. Ruebhart, D.R., et al. 2009. J. Toxicol. Environ. Health Part A. 72: 1567-1575. PMID: 20077231

8. Kaur, P., et al. 2010. Toxicology. 276: 73-78. PMID: 20637824

9. Mitchell, R.M. et al. 2011. Neurobiol. Aging. 32(6): 1114-1123. PMID: 19560233

10. Okamoto, A. et al. 2016. BMC Anesthesiol. 16(1): 104. PMID: 27776485

Physical State :
Solid
Solubility :
Soluble in 100% ethanol (25 mg/ml), methanol, water(slightly), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS( pH7.2) (~3 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
187-189° C
Boiling Point :
~405.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.57
IC50 :
Rattus norvegicus: EC5050 = 77.8 µM; COX2: IC50 = 150 nM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 3.6 µM (human); Bos taurus: IC50 = 5 µM; COX1: IC50 = 130 nM (human); Rattus norvegicus: IC50 = 14 µM; Brain: IC50 = 41.57 µM (Rattus norvegicus); MCF7 (Breast carcinoma cells): IC50 = 1461 µM (human); Radical scavenging activity: IC50 = 10.6 µM
pK Values :
pKa: 3.35
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
2
RTECS :
DJ2273000
PubChem CID :
40634
MDL Number :
MFCD00006846
EC Number :
258-422-8
Beilstein Registry :
1384051
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O

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Trolox  参考文献

See how others have used Trolox. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 30769341  2019. Phys Biol. 16: 035002.

PMID: # 28211872  2017. Cell Death Differ. 24: 731-746.

PMID: # 29162859  Kondratskyi, A. et al. 2017. Sci Rep. 7: 15896.

PMID: # 28223427  Noguchi, F. et al. 2017. Mol. Cancer Ther. 16: 936-947.

PMID: # 29038291  Goji, T.|Takahara, K.|Negishi, M.|Katoh, H.| et al. 2017. J. Biol. Chem. 292: 19721-19732.

PMID: # 28887471  Tang, J. et al. 2017. Sci Rep. 7: 10945.

PMID: # 27178823  Yin, P.|Jia, J.|Li, J.|Song, Y.|Zhang, Y.|Chen, F.| et al. 2016. Oncol. Res. 24: 65-72.

PMID: # 27383327  2016. Eur Rev Med Pharmacol Sci. 20: 2710-7.

PMID: # 26200654  Penzo-Méndez, AI. et al. 2015. PloS one. 10: e0132437.

PMID: # 25301069  Skliris, A. et al. 2015. Cell Death Differ. 22: 703-18.

Citations 1 to 10 of 18 total
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