TES, Free Acid CAS: 7365-44-8
MF: C6H15NO6S
MW: 229.25
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, a structural analog to Tris buffer.

TES, Free Acid (CAS 7365-44-8)

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別名: N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
アプリケーション: TES, Free Acid is N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, a structural analog to Tris buffer
CAS 番号: 7365-44-8
Purity: ≥99%
Molecular Weight: 229.25
Molecular Formula: C6H15NO6S
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* Refer to Certificate of Analysis for lot specific data (including water content).
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TES, Free Acid is a structural analog to Tris buffer. It is one of the ethanesulfonic acid series of biological buffers developed by Good et al. Good′s buffer criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range, and easily synthesized. TES probably exists in solution as a zwitterion. Because the pKa is 7.4 (physiological pH) this buffer has considerable potential for a variety of biological applications. A buffer using TES free acid can be prepared by titrating the free acid (sc-206102) with sodium hydroxide to the desired pH, using about a half-equivalent of NaOH. Alternatively, solutions of equimolar TES free acid and TES sodium (sc-264384) can be mixed to attain a buffer of the desired pH.


参考文献

1. Good, N.E., et al. 1966. Biochemistry. 5: 467-477. PMID: 5942950

Physical State :
Solid
Solubility :
Soluble in water (500 mg/ml).
保存方法 :
Store at room temperature
Melting Point :
226-228° C (lit.)
Boiling Point :
446.62° C (Predicted)
Density :
~1.55 g/cm3 (Predicted)
Refractive Index :
n20D ~1.57 (Predicted)
pK Values :
pKa: 7.4 at 25° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
1
PubChem CID :
81831
Merck Index :
14: 9176
MDL Number :
MFCD00007532
EC Number :
230-906-3
Beilstein Registry :
1957061
SMILES :
C(CS(=O)(=O)O)NC(CO)(CO)CO

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