TEMPOL CAS: 2226-96-2
MF: C9H18NO2
MW: 172.25
A superoxide dismutase mimetic that restores the effects of TNF-α.

TEMPOL (CAS 2226-96-2)

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同義語 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
アプリケーション: A superoxide dismutase mimetic that restores the effects of TNF-α
CAS 番号: 2226-96-2
Purity: ≥99%
Molecular Weight: 172.25
Molecular Formula: C9H18NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


参考文献

1. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
2. Xu, H., et al. 2004. Hypertension. 43: 329-334. PMID: 14707156
3. Khattab, M.M., 2006. Eur. J. Pharmacol. 548: 167-173. PMID: 16973155
4. Lipman, T., et al. 2006. Eur. J. Pharmacol. 549: 50-57. PMID: 16989807
5. Mariappan, N., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H2726-H2737. PMID: 17675574
6. Pires, P.W., et al. 2010. Microvasc Res. PMID: 20600163

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (1670 g/l) at 20° C, ethanol (100 mM), methanol, and DMSO (100 mM).
保存方法 :
Store at room temperature
Melting Point :
69-71° C (lit.)
Boiling Point :
269° C
Density :
1.19 g/cm3
IC50 :
Plasmodium falciparum K1: IC50 = 19 µg/ml; Plasmodium falciparum NF54: IC50 = 27 µg/ml
pK Values :
pKb: 5.15
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
1
RTECS :
TN8991000
PubChem CID :
137994
Merck Index :
14: 9141
MDL Number :
MFCD00006478
EC Number :
218-760-9
Beilstein Registry :
1422990
SMILES :
CC1(CC(CC(N1[O])(C)C)O)C

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TEMPOL  参考文献

See how others have used TEMPOL. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 30718685  Kornienko, JS.|Smirnova, IS.|Pugovkina, NA.|Ivanova, JS.|Shilina, MA.|Grinchuk, TM.|Shatrova, AN.|Aksenov, ND.|Zenin, VV.|Nikolsky, NN.|Lyublinskaya, OG.| et al. 2019. Sci Rep. 9: 1296.

PMID: # 30990365  Thangaraj, A.|Periyasamy, P.|Guo, ML.|Chivero, ET.|Callen, S.|Buch, S.| et al. 2019. Autophagy.

PMID: # 30535505  Xu, TZ.|Shen, XY.|Sun, LL.|Chen, YL.|Zhang, BQ.|Huang, DK.|Li, WZ.| et al. 2018. Int. J. Mol. Med.

PMID: # 27069531  Salvi, A. et al. 2016. Oxid Med Cell Longev. 2016: 5059043.

PMID: # 27679544  Steiner, I. et al. 2016. Radiol Oncol. 50: 280-8.

PMID: # 27088800  Wen, Z. et al. 2016. J. Clin. Invest. 126: 1953-67.

PMID: # 27778515  Morita, K.|Miyazaki, S.|Numako, C.|Ikeno, S.|Sasaki, R.|Nishimura, Y.|Ogino, C.|Kondo, A.| et al. 2016. Free Radic. Res. 50: 1319-1328.

PMID: # 25793256  Patki, G. et al. 2015. PLoS ONE. 10: e0117498.

PMID: # 25752964  Al-Shboul, O. et al. 2015. Canadian journal of physiology and pharmacology. 93: 405-11.

PMID: # 26000607  Zhang, M. et al. 2015. PloS one. 10: e0127386.

Citations 1 to 10 of 20 total
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