Stauprimide CAS: 154589-96-5
MF: C35H28N4O5
MW: 584.6
An indolocarbazole promoter of embryonic stem cell differentiation.

Stauprimide (CAS 154589-96-5)

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別名: N-Benzoyl-7-oxostaurosporine
アプリケーション: Stauprimide is an indolocarbazole promoter of embryonic stem cell differentiation
CAS 番号: 154589-96-5
Purity: >95%
Molecular Weight: 584.6
Molecular Formula: C35H28N4O5
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Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide.


参考文献

1. Zhu, Shoutian., et al., 2009. A small molecule primes embryonic stem cells for differentiation. Cell stem cell. 4(5): 416-26. PMID: 19427291

Physical State :
Solid
Derived From :
Streptomyces
Solubility :
Soluble in ethanol (slightly), methanol, DMSO (100 mg/ml), DMF, and water (limited).
保存方法 :
Store at -20° C
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.78 (Predicted)
IC50 :
Increases the efficiency of directed differentiation: EC5050 = 0.3 µM (Sox17+ /Sox7- cells)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD14635443
SMILES :
C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

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