SNC 162 (CAS 178803-51-5)

SNC 162 is a potent and selective non-peptide δ-opioid receptor (DOR) agonist (K_i = 0.63 nM). SNC 162 shows > 8000-fold selectivity over μ-opioid receptors.

参考文献

Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284. Calderon et al (1997) Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective d agonist (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80) and related novel nonpeptide d opioid receptor ligands. J.Med.Chem. 40 695. Negus et al (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J.Pharmacol.Exp.Ther. 286 362.