SNC 121 Dihydrochloride CAS: 159860-31-8
MF: C28H41N3O2•2HCl
MW: 524.55

SNC 121 Dihydrochloride (CAS 159860-31-8)

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別名: SNC 121 Dihydrochloride is known as a selective δ agonist.
アプリケーション: SNC 121 Dihydrochloride is a highly selective, non-peptide δ agonist and saturated analog of opioid receptor agonist SNC 80.
CAS 番号: 159860-31-8
Molecular Weight: 524.55
Molecular Formula: C28H41N3O22HCl
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* Refer to Certificate of Analysis for lot specific data (including water content).

SNC 121 Dihydrochloride is a highly selective, non-peptide δ agonist. SNC 121 Dihydrochloride is a saturated analog of the potent, selective δ opioid receptor agonist SNC 80. Compared to SNC 80, SNC 121 Dihydrochloride has a similar binding profile to its parent compound. Studies showed that treatment with SNC 121 Dihydrochloride resulted in the inhibition of Pattern-electroretinogram loss in hypertensive eyes. SNC 121 Dihydrochloride treatment also inhibited p38 MAP kinase activation in astrocytes.


参考文献

1. Ni et al (1995) Opioid peptide receptor studies 2. [3H]SNC-121, a novel, selective and high affinity ligand for opioid delta receptors. Analgesia 1 185.
2. Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284.
3. Patel, Hemal H., Anna Hsu, and Garrett J. Gross. "Delayed cardioprotection is mediated via a non-peptide δ opioid agonist, SNC-121, independent of opioid receptor stimulation." Basic research in cardiology 99.1 (2004): 38-45.
4. Abdul, Yasir, Naseem Akhter, and Shahid Husain. "Delta-opioid agonist SNC-121 protects retinal ganglion cell function in a chronic ocular hypertensive rat model." Investigative ophthalmology & visual science 54.3 (2013): 1816-1828.

Physical State :
Solid
Solubility :
Soluble in water (5mg/0.1ml), methanol, DMSO, and DMF.
保存方法 :
Store at room temperature
Refractive Index :
n20D 1.54 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
CCCN1CC(N(CC1C)C(C2=CC=C(C=C2)C(=O)N(CC)CC)C3=CC(=CC=C3)OC)C

Download SDS (MSDS)

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SNC 121 Dihydrochloride (CAS 159860-31-8)  参考文献

他の人がSNC 121 Dihydrochloride (CAS 159860-31-8)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 5 of 5 合計

PMID: # 33628191  Husain, S.|Zaidi, SAH.|Singh, S.|Guzman, W.|Mehrotra, S.| et al. 2021. Front Pharmacol. 12: 601404.

PMID: # 32915982  Invest. Ophthalmol. Vis. Sci. 17.

PMID: # 25329670  PLoS One. e110397.

PMID: # 33263714  Invest Ophthalmol Vis Sci. 4.

PMID: # 31715185  Life Sci. 116942.

引用 1 to 5 of 5 合計
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