Sinefungin CAS: 58944-73-3
MF: C15H23N7O5
MW: 381.39
A SAM analog and Dnmt inhibitor.

Sinefungin (CAS 58944-73-3)

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別名: Adenosylornithine
アプリケーション: Sinefungin is a SAM analog and Dnmt inhibitor
CAS 番号: 58944-73-3
Purity: >95%
Molecular Weight: 381.39
Molecular Formula: C15H23N7O5
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* Refer to Certificate of Analysis for lot specific data (including water content).

Sinefungin is a DNA methyltransferase (Dnmt) inhibitor and an analog of s-adenosyl-L-methionine (SAM) as indicated by previous studies. In studies investigating cytosine deamination by Dnmt, it was noted that the presence of sinefungin increased the rate of deamination 103 fold in the presence of its analog SAM, and 104 in the absence of SAM. This may suggest that sinefungin could be useful as a test compound in antiviral, anticancer, antiparasitic and antifungal applications. Additional studies indicate that sinefungin was able to inhibit RNA synthesis in a vaccinia virion preparation.


参考文献

1. Pugh, C.S., et al. 1978. J. Biol. Chem. 253: 4075-4077. PMID: 659406
2. Zingg, J.M., et al. 1996. Nucleic Acids Res. 24: 3267-3275. PMID: 8774911
3. Lin, Q., et al. 2001. J. Am. Chem. Soc. 123: 11608-11613. PMID: 11716715
4. Cheng, D., et al. 2004. J. Biol. Chem. 279: 23892-23899. PMID: 15056663

Physical State :
Solid
Solubility :
Soluble in water.
保存方法 :
Store at -20° C
Melting Point :
336.70° C (Predicted)
Boiling Point :
783.23° C at 760 mmHg (Predicted)
Density :
1.91 g/cm3 (Predicted)
Refractive Index :
n20D 1.83 (Predicted)
IC50 :
(PRMT1) Protein-arginine N-methyltransferase 1: IC50 = <1 µM (human); Leishmania donovani: IC50 = 1 µM (Leishmania donovani); (SET7/9) Histone-lysine N-methyltransferase SETD7: IC50 = 2.5 µM (human)
pK Values :
pKa: 2.44 (Predicted), pKb: 10.51 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
HE3140000
PubChem CID :
Merck Index :
14: 8544
MDL Number :
MFCD00057013
SMILES :
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O

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Sinefungin (CAS 58944-73-3)  参考文献

他の人がSinefungin (CAS 58944-73-3)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 3 of 3 合計

PMID: # 26202969  Liu, RJ. et al. 2015. Nucleic acids research. 43: 7489-503.

PMID: # 24128079  Fu, X. et al. 2014. Mol Ecol Resour. 14: 184-98.

PMID: # 25050323  Yadav, MK. et al. 2014. BioMed research international. 2014: 156987.

引用 1 to 3 of 3 合計
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